CHEBI:313639 - profenamine

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ChEBI Name profenamine
ChEBI ID CHEBI:313639
Definition A member of the class of phenothiazines that is phenothiazine in which the hydrogen attached to the nitrogen is substituted by a 2-(diethylamino)propyl group. An antimuscarinic, it is used as the hydrochloride for the symptomatic treatment of Parkinson's disease.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C19H24N2S
Net Charge 0
Average Mass 312.47200
Monoisotopic Mass 312.166
InChI InChI=1S/C19H24N2S/c1-4-20(5-2)15(3)14-21-16-10-6-8-12-18(16)22-19-13-9-7-11-17(19)21/h6-13,15H,4-5,14H2,1-3H3
InChIKey CDOZDBSBBXSXLB-UHFFFAOYSA-N
SMILES CCN(CC)C(C)CN1c2ccccc2Sc2ccccc12
Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): muscarinic antagonist
A drug that binds to but does not activate muscarinic cholinergic receptors, thereby blocking the actions of endogenous acetylcholine or exogenous agonists.
histamine antagonist
Histamine antagonists are the drugs that bind to but do not activate histamine receptors, thereby blocking the actions of histamine or histamine agonists.
adrenergic antagonist
An agent that binds to but does not activate adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists.
Application(s): muscarinic antagonist
A drug that binds to but does not activate muscarinic cholinergic receptors, thereby blocking the actions of endogenous acetylcholine or exogenous agonists.
antiparkinson drug
A drug used in the treatment of Parkinson's disease.
histamine antagonist
Histamine antagonists are the drugs that bind to but do not activate histamine receptors, thereby blocking the actions of histamine or histamine agonists.
adrenergic antagonist
An agent that binds to but does not activate adrenergic receptors thereby blocking the actions of endogenous or exogenous adrenergic agonists.
antidyskinesia agent
Any compound which can be used to treat or alleviate the symptoms of dyskinesia.
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ChEBI Ontology
Outgoing profenamine (CHEBI:313639) has role adrenergic antagonist (CHEBI:37887)
profenamine (CHEBI:313639) has role antidyskinesia agent (CHEBI:66956)
profenamine (CHEBI:313639) has role antiparkinson drug (CHEBI:48407)
profenamine (CHEBI:313639) has role histamine antagonist (CHEBI:37956)
profenamine (CHEBI:313639) has role muscarinic antagonist (CHEBI:48876)
profenamine (CHEBI:313639) is a phenothiazines (CHEBI:38093)
profenamine (CHEBI:313639) is a tertiary amino compound (CHEBI:50996)
Incoming profenamine hydrochloride (CHEBI:31568) has part profenamine (CHEBI:313639)
(R)-profenamine (CHEBI:60348) is a profenamine (CHEBI:313639)
(S)-profenamine (CHEBI:60349) is a profenamine (CHEBI:313639)
IUPAC Name
N,N-diethyl-1-(10H-phenothiazin-10-yl)propan-2-amine
INNs Sources
profenamina ChemIDplus
profénamine WHO MedNet
profenamine ChemIDplus
profenaminum ChemIDplus
Synonyms Sources
10-(2-diethylaminopropyl)phenothiazine ChemIDplus
10-[2-(diethylamino)-1-propyl]phenothiazine NIST Chemistry WebBook
10-[2-(diethylamino)-2-methylethyl]phenothiazine NIST Chemistry WebBook
10-[2-(diethylamino)propyl]phenothiazine NIST Chemistry WebBook
2-diethylamino-1-propyl-N-dibenzoparathiazine ChemIDplus
ethopropazine ChemIDplus
N,N-diethyl-1-(10H-phenothiazin-10-yl)-2-propanamine NIST Chemistry WebBook
N,N-diethyl-α-methyl-10H-phenothiazine-10-ethanamine NIST Chemistry WebBook
Manual Xrefs Databases
1086 DrugCentral
D08426 KEGG DRUG
DB00392 DrugBank
Ethopropazine Wikipedia
HMDB0014536 HMDB
LSM-1342 LINCS
US2607773 Patent
View more database links
Registry Numbers Types Sources
522-00-9 CAS Registry Number NIST Chemistry WebBook
522-00-9 CAS Registry Number KEGG DRUG
522-00-9 CAS Registry Number ChemIDplus
89828 Reaxys Registry Number Reaxys
Citations Waiting for Citations Types Sources
17459789 PubMed citation Europe PMC
6539933 PubMed citation Europe PMC
Last Modified
22 February 2017