CHEBI:31190 - alminoprofen

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ChEBI Name alminoprofen
ChEBI ID CHEBI:31190
Definition A substituted aniline that is ibuprofen in which the isobutyl group is replaced by a (2-methylprop-2-en-1-yl)amino group. A non-steroidal anti-inflammatory drug, it is used for treatment of inflammatory and rheumatic disorders.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C13H17NO2
Net Charge 0
Average Mass 219.27960
Monoisotopic Mass 219.126
InChI InChI=1S/C13H17NO2/c1-9(2)8-14-12-6-4-11(5-7-12)10(3)13(15)16/h4-7,10,14H,1,8H2,2-3H3,(H,15,16)
InChIKey FPHLBGOJWPEVME-UHFFFAOYSA-N
SMILES CC(C(O)=O)c1ccc(NCC(C)=C)cc1
Roles Classification
Chemical Role(s): Bronsted acid
A molecular entity capable of donating a hydron to an acceptor (Bronsted base).
(via oxoacid )
Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor
A lipoxygenase inhibitor that interferes with the action of arachidonate 5-lipoxygenase (EC 1.13.11.34).
EC 3.1.1.4 (phospholipase A2) inhibitor
An EC 3.1.1.* (carboxylic ester hydrolase) inhibitor that interferes with the action of phospholipase A2 (EC 3.1.1.4).
cyclooxygenase 2 inhibitor
A cyclooxygenase inhibitor that interferes with the action of cyclooxygenase 2.
non-narcotic analgesic
A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.
Application(s): non-steroidal anti-inflammatory drug
An anti-inflammatory drug that is not a steroid. In addition to anti-inflammatory actions, non-steroidal anti-inflammatory drugs have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins.
antirheumatic drug
A drug used to treat rheumatoid arthritis.
antipyretic
A drug that prevents or reduces fever by lowering the body temperature from a raised state. An antipyretic will not affect the normal body temperature if one does not have fever. Antipyretics cause the hypothalamus to override an interleukin-induced increase in temperature. The body will then work to lower the temperature and the result is a reduction in fever.
non-narcotic analgesic
A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.
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ChEBI Ontology
Outgoing alminoprofen (CHEBI:31190) has role antipyretic (CHEBI:35493)
alminoprofen (CHEBI:31190) has role antirheumatic drug (CHEBI:35842)
alminoprofen (CHEBI:31190) has role cyclooxygenase 2 inhibitor (CHEBI:50629)
alminoprofen (CHEBI:31190) has role EC 1.13.11.34 (arachidonate 5-lipoxygenase) inhibitor (CHEBI:64964)
alminoprofen (CHEBI:31190) has role EC 3.1.1.4 (phospholipase A2) inhibitor (CHEBI:50469)
alminoprofen (CHEBI:31190) has role non-narcotic analgesic (CHEBI:35481)
alminoprofen (CHEBI:31190) has role non-steroidal anti-inflammatory drug (CHEBI:35475)
alminoprofen (CHEBI:31190) is a amino acid (CHEBI:33709)
alminoprofen (CHEBI:31190) is a monocarboxylic acid (CHEBI:25384)
alminoprofen (CHEBI:31190) is a secondary amino compound (CHEBI:50995)
alminoprofen (CHEBI:31190) is a substituted aniline (CHEBI:48975)
IUPAC Name
2-{4-[(2-methylprop-2-en-1-yl)amino]phenyl}propanoic acid
INNs Sources
alminoprofen ChemIDplus
alminoprofene ChemIDplus
alminoprofeno ChemIDplus
alminoprofenum ChemIDplus
Synonyms Sources
2-(4-((2-Methylallyl)amino)phenyl)propansaeure ChemIDplus
2-{4-[(2-methylprop-2-en-1-yl)amino]phenyl}propionic acid ChEBI
acide (methallylamino-4 phenyl)-2 propionique ChemIDplus
α-methyl-4-[(2-methyl-2-propenyl)amino]benzeneacetic acid ChEBI
BRN 2373633 ChemIDplus
EB 382 ChemIDplus
EB-382 ChemIDplus
p-((2-Methylallyl)amino)hydratropic acid ChemIDplus
p-((2-methylallyl)amino)hydratropic acid ChemIDplus
Brand Name Source
Minalfen KEGG DRUG
Manual Xrefs Databases
126 DrugCentral
Alminoprofen Wikipedia
D01513 KEGG DRUG
FR2137211 Patent
US3957850 Patent
View more database links
Registry Numbers Types Sources
39718-89-3 CAS Registry Number KEGG DRUG
39718-89-3 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
1783327 PubMed citation Europe PMC
2076851 PubMed citation Europe PMC
23306154 PubMed citation Europe PMC
24036363 PubMed citation Europe PMC
4066887 PubMed citation Europe PMC
9933032 PubMed citation Europe PMC
Last Modified
22 February 2017