CHEBI:31183 - alclofenac

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ChEBI Name alclofenac
ChEBI ID CHEBI:31183
Definition An aromatic ether in which the ether oxygen links an allyl group to the 4-position of (3-chlorophenyl)acetic acid.A non-steroidal anti-inflammatory drug, it was withdrawn from the UK market in 1979 due to concerns with its association with vasculitis and rash.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C11H11ClO3
Net Charge 0
Average Mass 226.65600
Monoisotopic Mass 226.040
InChI InChI=1S/C11H11ClO3/c1-2-5-15-10-4-3-8(6-9(10)12)7-11(13)14/h2-4,6H,1,5,7H2,(H,13,14)
InChIKey ARHWPKZXBHOEEE-UHFFFAOYSA-N
SMILES OC(=O)Cc1ccc(OCC=C)c(Cl)c1
Roles Classification
Chemical Role(s): Bronsted acid
A molecular entity capable of donating a hydron to an acceptor (Bronsted base).
(via oxoacid )
Biological Role(s): non-narcotic analgesic
A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.
Application(s): non-steroidal anti-inflammatory drug
An anti-inflammatory drug that is not a steroid. In addition to anti-inflammatory actions, non-steroidal anti-inflammatory drugs have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins.
non-narcotic analgesic
A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.
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ChEBI Ontology
Outgoing alclofenac (CHEBI:31183) has role non-narcotic analgesic (CHEBI:35481)
alclofenac (CHEBI:31183) has role non-steroidal anti-inflammatory drug (CHEBI:35475)
alclofenac (CHEBI:31183) is a aromatic ether (CHEBI:35618)
alclofenac (CHEBI:31183) is a monocarboxylic acid (CHEBI:25384)
alclofenac (CHEBI:31183) is a monochlorobenzenes (CHEBI:83403)
IUPAC Name
[3-chloro-4-(prop-2-en-1-yloxy)phenyl]acetic acid
INNs Sources
alclofenac ChemIDplus
alclofénac WHO MedNet
alclofenaco ChemIDplus
alclofenacum ChemIDplus
Synonyms Sources
(4-Allyloxy-3-chlorphenyl)essigsäure ChemIDplus
3-Chloro-4-(2-propenyloxy)benzeneacetic acid ChemIDplus
[4-(allyloxy)-3-chlorophenyl]acetic acid IUPAC
Manual Xrefs Databases
107 DrugCentral
Alclofenac Wikipedia
BE704368 Patent
D01252 KEGG DRUG
View more database links
Registry Numbers Types Sources
2116510 Reaxys Registry Number Reaxys
22131-79-9 CAS Registry Number ChemIDplus
22131-79-9 CAS Registry Number KEGG DRUG
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Last Modified
22 February 2017