CHEBI:31159 - aceclofenac

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ChEBI Name aceclofenac
ChEBI ID CHEBI:31159
Definition A monocarboxylic acid that is the carboxymethyl ester of diclofenac. A non-steroidal anti-inflammatory drug related to diclofenac, it is used in the management of osteoarthritis, rheumatoid arthritis, and ankylosing spondylitis.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C16H13Cl2NO4
Net Charge 0
Average Mass 354.18500
Monoisotopic Mass 353.022
InChI InChI=1S/C16H13Cl2NO4/c17-11-5-3-6-12(18)16(11)19-13-7-2-1-4-10(13)8-15(22)23-9-14(20)21/h1-7,19H,8-9H2,(H,20,21)
InChIKey MNIPYSSQXLZQLJ-UHFFFAOYSA-N
SMILES OC(=O)COC(=O)Cc1ccccc1Nc1c(Cl)cccc1Cl
Roles Classification
Chemical Role(s): Bronsted acid
A molecular entity capable of donating a hydron to an acceptor (Bronsted base).
(via oxoacid )
Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor
A compound or agent that combines with cyclooxygenases (EC 1.14.99.1) and thereby prevents its substrate-enzyme combination with arachidonic acid and the formation of icosanoids, prostaglandins, and thromboxanes.
non-narcotic analgesic
A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.
Application(s): non-steroidal anti-inflammatory drug
An anti-inflammatory drug that is not a steroid. In addition to anti-inflammatory actions, non-steroidal anti-inflammatory drugs have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins.
non-narcotic analgesic
A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.
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ChEBI Ontology
Outgoing aceclofenac (CHEBI:31159) has functional parent diclofenac (CHEBI:47381)
aceclofenac (CHEBI:31159) has role EC 1.14.99.1 (prostaglandin-endoperoxide synthase) inhibitor (CHEBI:35544)
aceclofenac (CHEBI:31159) has role non-narcotic analgesic (CHEBI:35481)
aceclofenac (CHEBI:31159) has role non-steroidal anti-inflammatory drug (CHEBI:35475)
aceclofenac (CHEBI:31159) is a amino acid (CHEBI:33709)
aceclofenac (CHEBI:31159) is a carboxylic ester (CHEBI:33308)
aceclofenac (CHEBI:31159) is a dichlorobenzene (CHEBI:23697)
aceclofenac (CHEBI:31159) is a monocarboxylic acid (CHEBI:25384)
aceclofenac (CHEBI:31159) is a secondary amino compound (CHEBI:50995)
IUPAC Name
(2-{2-[(2,6-dichlorophenyl)amino]phenyl}acetoxy)acetic acid
INNs Sources
acéclofénac WHO MedNet
aceclofenac ChemIDplus
aceclofenaco ChemIDplus
aceclofenacum ChemIDplus
Synonyms Sources
2-[(2',6'-dichlorophenyl)amino]phenylacetoxyacetic acid ChEBI
2-[(2,6-dichlorophenyl)amino]benzeneacetic acid carboxymethyl ester ChEBI
2-[(2,6-dichlorophenyl)amino]phenylacetoxyacetic acid ChEBI
glycolic acid [o-(2,6-dichloroanilino)phenyl]acetate ester ChEBI
PR-82/3 ChEBI
Brand Names Sources
Cincofen ChEBI
Clanza ChEBI
Hifenac ChEBI
Manual Xrefs Databases
43 DrugCentral
Aceclofenac Wikipedia
D01545 KEGG DRUG
ES8404783 Patent
LSM-5762 LINCS
US4548952 Patent
View more database links
Registry Numbers Types Sources
4884476 Reaxys Registry Number Reaxys
89796-99-6 CAS Registry Number ChemIDplus
89796-99-6 CAS Registry Number KEGG DRUG
Citations Waiting for Citations Types Sources
11511027 PubMed citation Europe PMC
22807412 PubMed citation Europe PMC
23261744 PubMed citation Europe PMC
23944964 PubMed citation Europe PMC
Last Modified
22 February 2017