CHEBI:2972 - baclofen

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ChEBI Name baclofen
ChEBI ID CHEBI:2972
Definition A monocarboxylic acid that is butanoic acid substituted by an amino group at position 4 and a 4-chlorophenyl group at position 3. It acts as a central nervous system depressant, GABA agonist and muscle relaxant.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C10H12ClNO2
Net Charge 0
Average Mass 213.66100
Monoisotopic Mass 213.056
InChI InChI=1S/C10H12ClNO2/c11-9-3-1-7(2-4-9)8(6-12)5-10(13)14/h1-4,8H,5-6,12H2,(H,13,14)
InChIKey KPYSYYIEGFHWSV-UHFFFAOYSA-N
SMILES NCC(CC(O)=O)c1ccc(Cl)cc1
Roles Classification
Chemical Role(s): Bronsted acid
A molecular entity capable of donating a hydron to an acceptor (Bronsted base).
(via oxoacid )
Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): GABA agonist
A drug that binds to and activates gamma-aminobutyric acid receptors.
Application(s): muscle relaxant
A drug used to produce muscle relaxation (excepting neuromuscular blocking agents). Its primary clinical and therapeutic use is the treatment of muscle spasm and immobility associated with strains, sprains, and injuries of the back and, to a lesser degree, injuries to the neck. Also used for the treatment of a variety of clinical conditions that have in common only the presence of skeletal muscle hyperactivity, for example, the muscle spasms that can occur in multiple sclerosis.
central nervous system depressant
A loosely defined group of drugs that tend to reduce the activity of the central nervous system.
GABA agonist
A drug that binds to and activates gamma-aminobutyric acid receptors.
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ChEBI Ontology
Outgoing baclofen (CHEBI:2972) has role central nervous system depressant (CHEBI:35488)
baclofen (CHEBI:2972) has role GABA agonist (CHEBI:51373)
baclofen (CHEBI:2972) has role muscle relaxant (CHEBI:51371)
baclofen (CHEBI:2972) is a γ-amino acid (CHEBI:33707)
baclofen (CHEBI:2972) is a monocarboxylic acid (CHEBI:25384)
baclofen (CHEBI:2972) is a monochlorobenzenes (CHEBI:83403)
baclofen (CHEBI:2972) is a primary amino compound (CHEBI:50994)
IUPAC Name
4-amino-3-(4-chlorophenyl)butanoic acid
INNs Sources
baclofen WHO MedNet
baclofène WHO MedNet
baclofeno WHO MedNet
baclofenum WHO MedNet
Synonyms Sources
(+-)-Baclofen ChemIDplus
4-Amino-3-(4-chlorophenyl)butyric acid ChemIDplus
beta-(4-Chlorophenyl)gaba ChemIDplus
beta-(Aminomethyl)-4-chlorobenzenepropanoic acid ChemIDplus
beta-(Aminomethyl)-p-chlorohydrocinnamic acid ChemIDplus
beta-(p-Chlorophenyl)-gamma-aminobutyric acid ChemIDplus
DL-4-Amino-3-p-chlorophenylbutanoic acid ChemIDplus
DL-Baclofen ChemIDplus
gamma-Amino-beta-(p-chlorophenyl)butyric acid ChemIDplus
Manual Xrefs Databases
282 DrugCentral
Baclofen Wikipedia
D00241 KEGG DRUG
DB00181 DrugBank
HMDB0014327 HMDB
LSM-5169 LINCS
NL6407755 Patent
US3471548 Patent
View more database links
Registry Numbers Types Sources
1134-47-0 CAS Registry Number ChemIDplus
1134-47-0 CAS Registry Number NIST Chemistry WebBook
2104494 Reaxys Registry Number Reaxys
2104494 Beilstein Registry Number Beilstein
Citations Waiting for Citations Types Sources
11772961 PubMed citation Europe PMC
18682277 PubMed citation Europe PMC
18824012 PubMed citation Europe PMC
Last Modified
22 February 2017