CHEBI:291342 - desloratadine

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ChEBI Name desloratadine
ChEBI ID CHEBI:291342
Definition Loratadine in which the ethoxycarbonyl group attached to the piperidine ring is replaced by hydrogen. The major metabolite of loratidine, desloratadine is an antihistamine which is used for the symptomatic relief of allergic conditions including rhinitis and chronic urticaria. It does not readily enter the central nervous system, so does not cause drowsiness.
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Formula C19H19ClN2
Net Charge 0
Average Mass 310.82100
Monoisotopic Mass 310.124
InChI InChI=1S/C19H19ClN2/c20-16-5-6-17-15(12-16)4-3-14-2-1-9-22-19(14)18(17)13-7-10-21-11-8-13/h1-2,5-6,9,12,21H,3-4,7-8,10-11H2
InChIKey JAUOIFJMECXRGI-UHFFFAOYSA-N
SMILES Clc1ccc2c(CCc3cccnc3C2=C2CCNCC2)c1
Roles Classification
Biological Role(s): H1-receptor antagonist
H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine.
cholinergic antagonist
Any drug that binds to but does not activate cholinergic receptors, thereby blocking the actions of acetylcholine or cholinergic agonists.
Application(s): H1-receptor antagonist
H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine.
anti-allergic agent
A drug used to treat allergic reactions.
cholinergic antagonist
Any drug that binds to but does not activate cholinergic receptors, thereby blocking the actions of acetylcholine or cholinergic agonists.
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ChEBI Ontology
Outgoing desloratadine (CHEBI:291342) has role anti-allergic agent (CHEBI:50857)
desloratadine (CHEBI:291342) has role cholinergic antagonist (CHEBI:48873)
desloratadine (CHEBI:291342) has role H1-receptor antagonist (CHEBI:37955)
desloratadine (CHEBI:291342) is a benzocycloheptapyridine (CHEBI:48593)
IUPAC Name
8-chloro-11-(piperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine
INN Source
desloratadine KEGG DRUG
Synonyms Sources
8-Chloro-11-piperidin-4-ylidene-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine ChEMBL
8-chloro-6,11-dihydro-11-(4-piperidinylidene)-5H-benzo(5,6)cyclohepta(1,2-b)pyridine ChemIDplus
descarboethoxyloratadine ChemIDplus
DESLORATADINE ChEMBL
Manual Xrefs Databases
814 DrugCentral
D03693 KEGG DRUG
DB00967 DrugBank
Desloratadine Wikipedia
EP208855 Patent
LSM-5887 LINCS
US4659716 Patent
View more database links
Registry Numbers Types Sources
100643-71-8 CAS Registry Number KEGG DRUG
100643-71-8 CAS Registry Number ChemIDplus
4263164 Beilstein Registry Number Beilstein
Citations Waiting for Citations Types Sources
11844681 PubMed citation ChEMBL
15482930 PubMed citation ChEMBL
9934454 PubMed citation ChEMBL
Last Modified
22 February 2017