CHEBI:2654 - aminoglutethimide

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ChEBI Name aminoglutethimide
Definition A dicarboximide that is a six-membered cyclic compound having ethyl and 4-aminophenyl substituents at the 3-position.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C13H16N2O2
Net Charge 0
Average Mass 232.27830
Monoisotopic Mass 232.12118
InChI InChI=1S/C13H16N2O2/c1-2-13(8-7-11(16)15-12(13)17)9-3-5-10(14)6-4-9/h3-6H,2,7-8,14H2,1H3,(H,15,16,17)
SMILES CCC1(CCC(=O)NC1=O)c1ccc(N)cc1
Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): adrenergic agent
Any agent that acts on an adrenergic receptor or affects the life cycle of an adrenergic transmitter.
EC (aromatase) inhibitor
An EC 1.14.14.* (oxidoreductase acting on paired donors, incorporating of 1 atom of oxygen, with reduced flavin or flavoprotein as one donor) inhibitor which interferes with the action of aromatase (EC and so reduces production of estrogenic steroid hormones.
Application(s): antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
adrenergic agent
Any agent that acts on an adrenergic receptor or affects the life cycle of an adrenergic transmitter.
A drug used to prevent seizures or reduce their severity.
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ChEBI Ontology
Outgoing aminoglutethimide (CHEBI:2654) has functional parent piperidine-2,6-dione (CHEBI:5435)
aminoglutethimide (CHEBI:2654) has role adrenergic agent (CHEBI:37962)
aminoglutethimide (CHEBI:2654) has role anticonvulsant (CHEBI:35623)
aminoglutethimide (CHEBI:2654) has role antineoplastic agent (CHEBI:35610)
aminoglutethimide (CHEBI:2654) has role EC (aromatase) inhibitor (CHEBI:50790)
aminoglutethimide (CHEBI:2654) is a dicarboximide (CHEBI:35356)
aminoglutethimide (CHEBI:2654) is a piperidones (CHEBI:48589)
aminoglutethimide (CHEBI:2654) is a substituted aniline (CHEBI:48975)
Incoming (R)-aminoglutethimide (CHEBI:53788) is a aminoglutethimide (CHEBI:2654)
(S)-aminoglutethimide (CHEBI:53790) is a aminoglutethimide (CHEBI:2654)
INNs Sources
aminoglutethimide KEGG DRUG
aminoglutethimidum ChemIDplus
aminoglutetimida ChemIDplus
Synonyms Sources
2-(p-Aminophenyl)-2-ethylglutarimide ChemIDplus
3-Ethyl-3-(p-aminophenyl)-2,6-dioxopiperidine ChemIDplus
α-(p-Aminophenyl)-α-ethylglutarimide NIST Chemistry WebBook
DL-Aminoglutethimide DrugBank
p-Aminoglutethimide ChemIDplus
P-Aminoglutethimide DrugBank
Manual Xrefs Databases
164 DrugCentral
Aminoglutethimide Wikipedia
DB00357 DrugBank
HMDB0014501 HMDB
US2848455 Patent
View more database links
Registry Numbers Types Sources
125-84-8 CAS Registry Number NIST Chemistry WebBook
125-84-8 CAS Registry Number DrugBank
125-84-8 CAS Registry Number ChemIDplus
125-84-8 CAS Registry Number KEGG DRUG
210656 Reaxys Registry Number Reaxys
210656 Beilstein Registry Number Beilstein
Citations Waiting for Citations Types Sources
11916226 PubMed citation Europe PMC
17602675 PubMed citation Europe PMC
24350727 PubMed citation Europe PMC
Last Modified
22 February 2017