CHEBI:258351 - practolol

Main ChEBI Ontology Automatic Xrefs Reactions Pathways Models
ChEBI Name practolol
ChEBI ID CHEBI:258351
Definition N-(4-Hydroxyphenyl)acetamide in which the hydrogen of the phenolic hydroxy group is substituted by a 3-(isopropylaminoamino)-2-hydroxypropyl group. A selective beta blocker, it has been used in the emergency treatment of cardiac arrhythmias.
Stars This entity has been manually annotated by the ChEBI Team.
Secondary ChEBI IDs CHEBI:8348, CHEBI:101380
Supplier Information
Download Molfile XML SDF
more structures >>
Wikipedia License
Waiting for wikipedia content
Read full article at Wikipedia
Formula C14H22N2O3
Net Charge 0
Average Mass 266.33610
Monoisotopic Mass 266.163
InChI InChI=1S/C14H22N2O3/c1-10(2)15-8-13(18)9-19-14-6-4-12(5-7-14)16-11(3)17/h4-7,10,13,15,18H,8-9H2,1-3H3,(H,16,17)
InChIKey DURULFYMVIFBIR-UHFFFAOYSA-N
SMILES CC(C)NCC(O)COc1ccc(NC(C)=O)cc1
Roles Classification
Biological Role(s): beta-adrenergic antagonist
An agent that binds to but does not activate beta-adrenergic receptors thereby blocking the actions of endogenous or exogenous beta-adrenergic agonists. beta-Adrenergic antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches and anxiety.
Application(s): beta-adrenergic antagonist
An agent that binds to but does not activate beta-adrenergic receptors thereby blocking the actions of endogenous or exogenous beta-adrenergic agonists. beta-Adrenergic antagonists are used for treatment of hypertension, cardiac arrhythmias, angina pectoris, glaucoma, migraine headaches and anxiety.
anti-arrhythmia drug
A drug used for the treatment or prevention of cardiac arrhythmias. Anti-arrhythmia drugs may affect the polarisation-repolarisation phase of the action potential, its excitability or refractoriness, or impulse conduction or membrane responsiveness within cardiac fibres.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing practolol (CHEBI:258351) has role β-adrenergic antagonist (CHEBI:35530)
practolol (CHEBI:258351) has role anti-arrhythmia drug (CHEBI:38070)
practolol (CHEBI:258351) is a acetamides (CHEBI:22160)
practolol (CHEBI:258351) is a ethanolamines (CHEBI:23981)
practolol (CHEBI:258351) is a propanolamine (CHEBI:35533)
practolol (CHEBI:258351) is a secondary alcohol (CHEBI:35681)
practolol (CHEBI:258351) is a secondary amino compound (CHEBI:50995)
IUPAC Name
N-{4-[2-hydroxy-3-(propan-2-ylamino)propoxy]phenyl}acetamide
INNs Sources
practolol ChemIDplus
practololum ChemIDplus
Synonyms Sources
(±)-practolol ChEBI
1-(4-acetamidophenoxy)-3-isopropylamino-2-propanol ChemIDplus
4'-(2-hydroxy-3-(isopropylamino)propoxy)acetanilide ChemIDplus
N-(4-(2-hydroxy-3-((1-methylethyl)amino)propoxy)phenyl)acetamide ChemIDplus
Database Links Databases
3486 DrugCentral
C11696 KEGG COMPOUND
D05587 KEGG DRUG
DB01297 DrugBank
HMDB15411 HMDB
LSM-1531 LINCS
Practolol Wikipedia
US3408387 Patent
View more database links
Registry Numbers Types Sources
6673-35-4 CAS Registry Number KEGG COMPOUND
6673-35-4 CAS Registry Number ChemIDplus
Citation Waiting for Citations Type Source
6827543 PubMed citation ChEMBL
Last Modified
22 February 2017