CHEBI:170007 - nirmatrelvir

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ChEBI Name nirmatrelvir
ChEBI ID CHEBI:170007
Definition An azabicyclohexane that is (1R,5S)-3-azabicyclo[3.1.0]hexane substituted by {(1S)-1-cyano-2-[(3S)-2-oxopyrrolidin-3-yl]ethyl}aminoacyl, 3-methyl-N-(trifluoroacetyl)-L-valinamide, methyl and methyl groups at positions 2S, 3, 6 and 6, respectively. It is the first orally administered inhibitor of SARS-CoV-2 main protease developed by Pfizer and used in combination with ritonavir for the treatment of COVID-19.
Stars This entity has been manually annotated by the ChEBI Team.
Secondary ChEBI IDs CHEBI:192699
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Formula C23H32F3N5O4
Net Charge 0
Average Mass 499.535
Monoisotopic Mass 499.24064
InChI InChI=1S/C23H32F3N5O4/c1-21(2,3)16(30-20(35)23(24,25)26)19(34)31-10-13-14(22(13,4)5)15(31)18(33)29-12(9-27)8-11-6-7-28-17(11)32/h11-16H,6-8,10H2,1-5H3,(H,28,32)(H,29,33)(H,30,35)/t11-,12-,13-,14-,15-,16+/m0/s1
InChIKey LIENCHBZNNMNKG-OJFNHCPVSA-N
SMILES [H][C@]12CN([C@H](C(=O)N[C@@H](C[C@]3([H])CCNC3=O)C#N)[C@@]1([H])C2(C)C)C(=O)[C@@H](NC(=O)C(F)(F)F)C(C)(C)C
Roles Classification
Biological Role(s): EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor
An EC 3.4.22.* (cysteine endopeptidase) inhibitor that interferes with the action of SARS coronavirus main proteinase (EC 3.4.22.69).
anticoronaviral agent
Any antiviral agent which inhibits the activity of coronaviruses.
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ChEBI Ontology
Outgoing nirmatrelvir (CHEBI:170007) has role anticoronaviral agent (CHEBI:149553)
nirmatrelvir (CHEBI:170007) has role EC 3.4.22.69 (SARS coronavirus main proteinase) inhibitor (CHEBI:147285)
nirmatrelvir (CHEBI:170007) is a azabicyclohexane (CHEBI:170008)
nirmatrelvir (CHEBI:170007) is a nitrile (CHEBI:18379)
nirmatrelvir (CHEBI:170007) is a organofluorine compound (CHEBI:37143)
nirmatrelvir (CHEBI:170007) is a pyrrolidin-2-ones (CHEBI:74223)
nirmatrelvir (CHEBI:170007) is a pyrrolidinecarboxamide (CHEBI:46770)
nirmatrelvir (CHEBI:170007) is a secondary carboxamide (CHEBI:140325)
nirmatrelvir (CHEBI:170007) is a tertiary carboxamide (CHEBI:140326)
Incoming Paxlovid (CHEBI:192712) has part nirmatrelvir (CHEBI:170007)
IUPAC Name
(1R,2S,5S)-N-{(1S)-1-cyano-2-[(3S)-2-oxopyrrolidin-3-yl]ethyl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide
INNs Sources
nirmatrelvir WHO MedNet
nirmatrelvir WHO MedNet
nirmatrelvir WHO MedNet
nirmatrelvirum WHO MedNet
Synonyms Sources
PF 07321332 ChEBI
PF-07321332 ChemIDplus
PF07321332 ChEBI
Manual Xrefs Databases
D12244 KEGG DRUG
DB16691 DrugBank
Nirmatrelvir Wikipedia
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Registry Number Type Source
2628280-40-8 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
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PMC9232762 PubMed Central citation Europe PMC
PMC9264725 PubMed Central citation Europe PMC
Last Modified
15 July 2022
General Comment
2021-04-26 Further info: https://cen.acs.org/acs-news/acs-meeting-news/Pfizer-unveils-oral-SARS-CoV/99/i13