CHEBI:145365 - crenolanib

Main ChEBI Ontology Automatic Xrefs Reactions Pathways Models
ChEBI Name crenolanib
Definition A member of the class of benzimidazoles that is 1H-benzimidazole which is substituted by a 8-(4-aminopiperidin-1-yl)quinolin-2-yl group at position 1 and by a (3-methyloxetan-3-yl)methoxy group at position 5. It is an inhibitor of type III tyrosine kinases, PDGFRα/β and FLT3 (IC50 of 11, 3.2, and 4 nM). Currently under clinical development for the treatment of acute myeloid leukemia.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
Download Molfile XML SDF
more structures >>
Wikipedia License
Waiting for wikipedia content
Read full article at Wikipedia
Formula C26H29N5O2
Net Charge 0
Average Mass 443.551
Monoisotopic Mass 443.23213
InChI InChI=1S/C26H29N5O2/c1-26(14-32-15-26)16-33-20-6-7-22-21(13-20)28-17-31(22)24-8-5-18-3-2-4-23(25(18)29-24)30-11-9-19(27)10-12-30/h2-8,13,17,19H,9-12,14-16,27H2,1H3
Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): EC (receptor protein-tyrosine kinase) inhibitor
An EC 2.7.10.* (protein-tyrosine kinase) inhibitor that interferes with the action of receptor protein-tyrosine kinase (EC
apoptosis inducer
Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.
Application(s): angiogenesis inhibitor
An agent and endogenous substances that antagonize or inhibit the development of new blood vessels.
antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing crenolanib (CHEBI:145365) has role angiogenesis inhibitor (CHEBI:48422)
crenolanib (CHEBI:145365) has role antineoplastic agent (CHEBI:35610)
crenolanib (CHEBI:145365) has role apoptosis inducer (CHEBI:68495)
crenolanib (CHEBI:145365) has role EC (receptor protein-tyrosine kinase) inhibitor (CHEBI:62434)
crenolanib (CHEBI:145365) is a aminopiperidine (CHEBI:48588)
crenolanib (CHEBI:145365) is a aromatic ether (CHEBI:35618)
crenolanib (CHEBI:145365) is a benzimidazoles (CHEBI:22715)
crenolanib (CHEBI:145365) is a oxetanes (CHEBI:38784)
crenolanib (CHEBI:145365) is a quinolines (CHEBI:26513)
crenolanib (CHEBI:145365) is a tertiary amino compound (CHEBI:50996)
INNs Sources
crénolanib WHO MedNet
crenolanib WHO MedNet
crenolanib WHO MedNet
crenolanibum WHO MedNet
Synonyms Sources
1-(2-(5-((3-methyloxetan-3-yl)methoxy)-1H-benzo-[d]imidazol-1-yl)quinolin-8-yl)piperidin-4-amine ChEBI
1-(2-{5-[(3-methyloxetan-3-yl)methoxy]-1H-1,3-benzodiazol-1-yl}quinolin-8-yl)piperidin-4-amine ChEBI
1-[2-[5-[(3-methyl-3-oxetanyl)methoxy]-1-benzimidazolyl]-8-quinolyl]-4-piperidinamine ChEBI
1-[2-[5-[(3-methyl-3-oxetanyl)methoxy]-1H-benzimidazol-1-yl]-8-quinolinyl]-4-piperidinamine ChEBI
ARO 002 DrugBank
ARO-002 DrugBank
CP 868596 DrugBank
CP-868,596 DrugBank
CP-868596 DrugBank
CP868569 ChEBI
Manual Xrefs Databases
6T2 PDBeChem
Crenolanib Wikipedia
DB11832 DrugBank
View more database links
Registry Number Type Source
670220-88-9 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
19738123 PubMed citation Europe PMC
20959830 PubMed citation Europe PMC
22745105 PubMed citation Europe PMC
23644495 PubMed citation Europe PMC
24046014 PubMed citation Europe PMC
24132921 PubMed citation Europe PMC
24227820 PubMed citation Europe PMC
24263951 PubMed citation Europe PMC
24623852 PubMed citation Europe PMC
25328409 PubMed citation Europe PMC
25597754 PubMed citation Europe PMC
28433542 PubMed citation Europe PMC
28943249 PubMed citation Europe PMC
29137311 PubMed citation Europe PMC
29191878 PubMed citation Europe PMC
29312564 PubMed citation Europe PMC
29472720 PubMed citation Europe PMC
30651561 PubMed citation Europe PMC
30942519 PubMed citation Europe PMC
31235865 PubMed citation Europe PMC
31309543 PubMed citation Europe PMC
Last Modified
14 November 2019