(R)-lisofylline (CHEBI:143527)

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ChEBI Name	(R)-lisofylline

ChEBI ID	CHEBI:143527

ChEBI ASCII Name	(R)-lisofylline

Definition	A 1-(5-hydroxyhexyl)-3,7-dimethyl-3,7-dihydro-1H-purine-2,6-dione that has (R)-configuration. A synthetic small molecule which was under development for the treatment of type 1 diabetes mellitus.

Stars	This entity has been manually annotated by the ChEBI Team.

Submitter	TheOtherDave

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Formula

C13H20N4O3

Net Charge

Average Mass

280.328

Monoisotopic Mass

280.15354

InChI

InChI=1S/C13H20N4O3/c1-9(18)6-4-5-7-17-12(19)10-11(14-8-15(10)2)16(3)13(17)20/h8-9,18H,4-7H2,1-3H3/t9-/m1/s1

InChIKey

NSMXQKNUPPXBRG-SECBINFHSA-N

SMILES

C=12N(C=NC1N(C(N(C2=O)CCCC[C@H](O)C)=O)C)C

Roles Classification
Biological Role(s):	immunomodulator Biologically active substance whose activity affects or plays a role in the functioning of the immune system. metabolite Any intermediate or product resulting from metabolism. The term 'metabolite' subsumes the classes commonly known as primary and secondary metabolites. (via alkaloid )

Application(s):	anti-inflammatory agent Any compound that has anti-inflammatory effects. immunomodulator Biologically active substance whose activity affects or plays a role in the functioning of the immune system.

ChEBI Ontology
Outgoing	(R)-lisofylline (CHEBI:143527) has role anti-inflammatory agent (CHEBI:67079) (R)-lisofylline (CHEBI:143527) has role immunomodulator (CHEBI:50846) (R)-lisofylline (CHEBI:143527) is a 1-(5-hydroxyhexyl)-3,7-dimethyl-3,7-dihydro-1H-purine-2,6-dione (CHEBI:143565) (R)-lisofylline (CHEBI:143527) is enantiomer of (S)-lisofylline (CHEBI:143564)

Incoming	rac-lisofylline (CHEBI:143567) has part (R)-lisofylline (CHEBI:143527) (S)-lisofylline (CHEBI:143564) is enantiomer of (R)-lisofylline (CHEBI:143527)

IUPAC Name

1-[(5R)-5-hydroxyhexyl]-3,7-dimethyl-3,7-dihydro-1H-purine-2,6-dione

Synonyms	Sources
(−)-lisofylline	ChEBI
(R)-1-(5-hydroxyhexyl)-3,7-dimethylxanthine	ChEBI
(R)-LSF	ChEBI
1-(5R-hydroxyhexyl)-3,7-dimethylxanthine	ChEBI
1-[(5R)-5-hydroxyhexyl]-3,7-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione	DrugBank
1-[(R)-5-hydroxyhexyl]theobromine	ChEBI
CT 1501R	ChemIDplus
CT-1501R	ChEBI
lisophylline	ChemIDplus

Brand Name	Source
ProTec	KEGG DRUG

Last Modified

03 May 2019