A secondary amino compound consisting of two molecules of tacrine that are linked together through their exocyclic amino groups by a heptane-1,7-diyl chain. Bis(7)-tacrine is an acetylcholinesterase (AChE)inhibitor (IC50 0.40 nM, >1,000 times more potent than tacrine). It has also been found to protect against H2O2 -induced apoptosis in rat pheochromocytoma cells.
This entity has been manually annotated by the ChEBI Team.
An EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitor that interferes with the action of nitric oxide synthase (EC 188.8.131.52).
An EC 3.1.1.* (carboxylic ester hydrolase) inhibitor that interferes with the action of enzyme acetylcholinesterase (EC 184.108.40.206), which helps breaking down of acetylcholine into choline and acetic acid.
Links to ChEMBL are created automatically based on matching structures. The links are currently created every month (normally on the first day of each month), so there will be a period (between 1 day and 1 month) after the initial entry is visible on the ChEBI website before the links appear (in the Automatic Xrefs tab).
Charles Tapley Hoyt
Also referenced as CHEMBL32823 referenced: https://www.ebi.ac.uk/chembl/compound/inspect/CHEMBL32823. I'm surprised there's no cross-reference type for ChEMBL