CHEBI:135864 - methylprednisolone suleptanate

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ChEBI Name methylprednisolone suleptanate
Definition An organic sodium salt that is the monosodium salt of methylprednisolone 21-suleptanic acid ester. It is a prodrug of methylprednisolone developed by Pharmacia Corp for the treatment of asthma.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C33H48NO10S.Na
Net Charge 0
Average Mass 673.790
Monoisotopic Mass 673.28966
InChI InChI=1S/C33H49NO10S.Na/c1-21-17-23-24-12-14-33(40,32(24,3)19-26(36)30(23)31(2)13-11-22(35)18-25(21)31)27(37)20-44-29(39)10-8-6-5-7-9-28(38)34(4)15-16-45(41,42)43;/h11,13,18,21,23-24,26,30,36,40H,5-10,12,14-17,19-20H2,1-4H3,(H,41,42,43);/q;+1/p-1/t21-,23-,24-,26-,30+,31-,32-,33-;/m0./s1
SMILES [Na+].[H][C@@]12CC[C@](O)(C(=O)COC(=O)CCCCCCC(=O)N(C)CCS([O-])(=O)=O)[C@@]1(C)C[C@H](O)[C@@]1([H])[C@@]2([H])C[C@H](C)C2=CC(=O)C=C[C@]12C
Roles Classification
Biological Role(s): glucocorticoid receptor agonist
An agonist that selectively binds to and activates a glucocorticoid receptor.
Application(s): anti-inflammatory agent
Any compound that has anti-inflammatory effects.
A compound that, on administration, must undergo chemical conversion by metabolic processes before becoming the pharmacologically active drug for which it is a prodrug.
anti-asthmatic drug
A drug used to treat asthma.
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ChEBI Ontology
Outgoing methylprednisolone suleptanate (CHEBI:135864) has part methylprednisolone 21-suleptanic acid ester(1−) (CHEBI:156481)
methylprednisolone suleptanate (CHEBI:135864) has role anti-asthmatic drug (CHEBI:49167)
methylprednisolone suleptanate (CHEBI:135864) has role anti-inflammatory agent (CHEBI:67079)
methylprednisolone suleptanate (CHEBI:135864) has role glucocorticoid receptor agonist (CHEBI:63562)
methylprednisolone suleptanate (CHEBI:135864) has role prodrug (CHEBI:50266)
methylprednisolone suleptanate (CHEBI:135864) is a organic sodium salt (CHEBI:38700)
sodium 2-[{8-[(11β,17-dihydroxy-6α-methyl-3,20-dioxopregna-1,4-dien-21-yl)oxy]-8-oxooctanoyl}(methyl)amino]ethanesulfonate
INNs Sources
methylprednisolone suleptanate WHO MedNet
methylprednisoloni suleptanas WHO MedNet
suleptanate de méthylprednisolone WHO MedNet
suleptanato de metilprednisolona WHO MedNet
Synonyms Sources
methylprednisolone suleptanate sodium DrugCentral
methylprednisolone suleptanate sodium salt DrugCentral
PNU 67590A ChemIDplus
PNU-67590A ChEBI
sodium 2-[{8-[(11β,17-dihydroxy-6α-methyl-3,20-dioxopregna-1,4-dien-21-yl)oxy]-8-oxooctanoyl}(methyl)amino]ethane-1-sulfonate IUPAC
U-67,590A ChemIDplus
U-67590A ChEBI
Brand Names Sources
Medrosol ChemIDplus
Promedrol ChemIDplus
Manual Xrefs Databases
1772 DrugCentral
Methylprednisolone_suleptanate Wikipedia
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Registry Number Type Source
90350-40-6 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
11249603 PubMed citation Europe PMC
1509198 PubMed citation Europe PMC
1665309 PubMed citation Europe PMC
2681792 PubMed citation Europe PMC
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7505356 PubMed citation Europe PMC
7682130 PubMed citation Europe PMC
7876403 PubMed citation Europe PMC
8028233 PubMed citation Europe PMC
9039715 PubMed citation Europe PMC
9327445 PubMed citation Europe PMC
9452975 PubMed citation Europe PMC
Last Modified
09 September 2020