CHEBI:135595 - fendosal

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ChEBI Name fendosal
ChEBI ID CHEBI:135595
Definition A benzoindole that is 4,5-dihydro-3H-benzo[e]indole in which the nitrogen is substituted by a 3-carboxy-4-hydroxyphenyl group. A non-narcotic analgesic and non-steroidal anti-inflammatory drug, it has greater analgesic and inflammatory responses than aspirin but with less gastrointestinal toxicity.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
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Formula C25H19NO3
Net Charge 0
Average Mass 381.424
Monoisotopic Mass 381.13649
InChI InChI=1S/C25H19NO3/c27-24-13-11-18(14-21(24)25(28)29)26-22-12-10-16-6-4-5-9-19(16)20(22)15-23(26)17-7-2-1-3-8-17/h1-9,11,13-15,27H,10,12H2,(H,28,29)
InChIKey HAWWPSYXSLJRBO-UHFFFAOYSA-N
SMILES C(O)(=O)C=1C=C(N2C3=C(C=C2C4=CC=CC=C4)C=5C(CC3)=CC=CC5)C=CC1O
Roles Classification
Chemical Role(s): Bronsted acid
A molecular entity capable of donating a hydron to an acceptor (Bronsted base).
(via oxoacid )
Biological Role(s): non-narcotic analgesic
A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.
Application(s): non-steroidal anti-inflammatory drug
An anti-inflammatory drug that is not a steroid. In addition to anti-inflammatory actions, non-steroidal anti-inflammatory drugs have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins.
non-narcotic analgesic
A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.
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ChEBI Ontology
Outgoing fendosal (CHEBI:135595) has role non-narcotic analgesic (CHEBI:35481)
fendosal (CHEBI:135595) has role non-steroidal anti-inflammatory drug (CHEBI:35475)
fendosal (CHEBI:135595) is a benzoindole (CHEBI:38111)
fendosal (CHEBI:135595) is a monohydroxybenzoic acid (CHEBI:25389)
fendosal (CHEBI:135595) is a pyrroles (CHEBI:26455)
IUPAC Name
2-hydroxy-5-(2-phenyl-4,5-dihydro-3H-benzo[e]indol-3-yl)benzoic acid
INNs Sources
fendosal WHO MedNet
fendosal WHO MedNet
fendosal WHO MedNet
fendosalum WHO MedNet
Synonyms Sources
3-(3-carboxy-4-hydroxyphenyl)-2-phenyl-4,5-dihydro-3H-benz(e)indole ChemIDplus
5-(4,5-dihydro-2-phenyl-3H-benz(e)indol-3-yl)-2-hydroxybenzoic acid ChemIDplus
5-(4,5-dihydro-2-phenyl-3H-benzo[e]indol-3-yl)salicylic acid ChEBI
HP 129 DrugCentral
Brand Name Source
Alnovin KEGG DRUG
Manual Xrefs Databases
3224 DrugCentral
D04145 KEGG DRUG
View more database links
Registry Numbers Types Sources
1665211 Reaxys Registry Number Reaxys
53597-27-6 CAS Registry Number ChemIDplus
53597-27-6 CAS Registry Number DrugCentral
Citations Waiting for Citations Types Sources
1249813 PubMed citation Europe PMC
307337 PubMed citation Europe PMC
343968 PubMed citation Europe PMC
3872688 PubMed citation Europe PMC
6113117 PubMed citation Europe PMC
6344034 PubMed citation Europe PMC
6393076 PubMed citation Europe PMC
6969854 PubMed citation Europe PMC
7448343 PubMed citation Europe PMC
Last Modified
22 January 2018