CHEBI:135281 - neticonazole

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ChEBI Name neticonazole
Definition An enamine that is ethene which is substituted at positions 1, 1, and 2 by o-pentoxyphenyl, 1H-imidazol-1-yl, and methylthio groups, respectively (the E isomer). An inhibitor of P450-dependent C-14α-demethylation of lanosterol (preventing conversion to ergosterol and inhibiting cell wall synthesis in fungi), it is used in Japan (generally as the corresponding hydrochloride salt) as an antifungal drug for the treatment of superficial skin infections.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C17H22N2OS
Net Charge 0
Average Mass 302.436
Monoisotopic Mass 302.14528
InChI InChI=1S/C17H22N2OS/c1-3-4-7-12-20-17-9-6-5-8-15(17)16(13-21-2)19-11-10-18-14-19/h5-6,8-11,13-14H,3-4,7,12H2,1-2H3/b16-13+
Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): antifungal drug
Any antifungal agent used to prevent or treat fungal infections in humans or animals.
(via conazole antifungal drug )
(via imidazole antifungal drug )
EC (sterol 14alpha-demethylase) inhibitor
An EC 1.14.13.* (oxidoreductase acting on paired donors, incorporating 1 atom of oxygen, with NADH or NADPH as one donor) inhibitor that interferes with the action of EC (sterol 14alpha-demethylase).
ergosterol biosynthesis inhibitor
Any compound that inhibits one or more steps in the pathway leading to the synthesis of ergosterol.
(via conazole antifungal agent )
antifungal agent
An antimicrobial agent that destroys fungi by suppressing their ability to grow or reproduce.
(via conazole antifungal agent )
(via imidazole antifungal agent )
Application(s): antifungal drug
Any antifungal agent used to prevent or treat fungal infections in humans or animals.
(via conazole antifungal drug )
(via imidazole antifungal drug )
View more via ChEBI Ontology
ChEBI Ontology
Outgoing neticonazole (CHEBI:135281) has role antifungal drug (CHEBI:86327)
neticonazole (CHEBI:135281) has role EC (sterol 14α-demethylase) inhibitor (CHEBI:77884)
neticonazole (CHEBI:135281) is a aromatic ether (CHEBI:35618)
neticonazole (CHEBI:135281) is a benzenes (CHEBI:22712)
neticonazole (CHEBI:135281) is a conazole antifungal drug (CHEBI:87071)
neticonazole (CHEBI:135281) is a enamine (CHEBI:47989)
neticonazole (CHEBI:135281) is a imidazole antifungal drug (CHEBI:87069)
neticonazole (CHEBI:135281) is a imidazoles (CHEBI:24780)
neticonazole (CHEBI:135281) is a methyl sulfide (CHEBI:86315)
neticonazole (CHEBI:135281) is conjugate base of neticonazole(1+) (CHEBI:141384)
Incoming neticonazole(1+) (CHEBI:141384) is conjugate acid of neticonazole (CHEBI:135281)
INNs Sources
neticonazol ChemIDplus
néticonazole ChEBI
neticonazole ChemIDplus
neticonazolum ChemIDplus
Brand Name Source
Atolant ChEBI
Manual Xrefs Databases
1902 DrugCentral
CA2458026 Patent
EP1568366 Patent
EP227011 Patent
Neticonazole Wikipedia
US4740601 Patent
View more database links
Registry Numbers Types Sources
130726-68-0 CAS Registry Number DrugCentral
130726-68-0 CAS Registry Number ChemIDplus
5381743 Reaxys Registry Number Reaxys
Citations Waiting for Citations Types Sources
11156023 PubMed citation Europe PMC
16651719 PubMed citation Europe PMC
8254891 PubMed citation Europe PMC
8734665 PubMed citation Europe PMC
9062749 PubMed citation Europe PMC
Last Modified
16 July 2018