CHEBI:134602 - MI-63

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ChEBI Name MI-63
Definition An azaspiro compound resulting from the formal fusion of position 3 of 6-chloro-oxindole with position 3 of (2R,3SS5S)-3-(3-chloro-2-fluorophenyl)-5-(2,2-dimethylpropyl)-N-[2-(morpholin-4-yl)ethyl]pyrrolidine-2-carboxamide. It is a potent inhibitor of the MDM2-p53 interaction.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C29H35Cl2FN4O3
Net Charge 0
Average Mass 577.519
Monoisotopic Mass 576.207
InChI InChI=1S/C29H35Cl2FN4O3/c1-28(2,3)16-22-29(19-8-7-17(30)15-21(19)34-27(29)38)23(18-5-4-6-20(31)24(18)32)25(35-22)26(37)33-9-10-36-11-13-39-14-12-36/h4-8,15,22-23,25,35H,9-14,16H2,1-3H3,(H,33,37)(H,34,38)/t22-,23+,25-,29+/m1/s1
SMILES O=C(NCCN1CCOCC1)[C@@H]2N[C@@H]([C@@]3(C4=CC=C(C=C4NC3=O)Cl)[C@]2(C=5C(=C(C=CC5)Cl)F)[H])CC(C)(C)C
Roles Classification
Biological Role(s): apoptosis inducer
Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.
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ChEBI Ontology
Outgoing MI-63 (CHEBI:134602) has role apoptosis inducer (CHEBI:68495)
MI-63 (CHEBI:134602) is a azaspiro compound (CHEBI:35624)
MI-63 (CHEBI:134602) is a monochlorobenzenes (CHEBI:83403)
MI-63 (CHEBI:134602) is a monofluorobenzenes (CHEBI:83575)
MI-63 (CHEBI:134602) is a morpholines (CHEBI:38785)
MI-63 (CHEBI:134602) is a oxindoles (CHEBI:38459)
MI-63 (CHEBI:134602) is a pyrrolidines (CHEBI:38260)
MI-63 (CHEBI:134602) is a secondary carboxamide (CHEBI:140325)
Registry Number Type Source
10506427 Reaxys Registry Number Reaxys
Citations Waiting for Citations Types Sources
19707204 PubMed citation Europe PMC
20423286 PubMed citation Europe PMC
21725357 PubMed citation Europe PMC
24921920 PubMed citation Europe PMC
25181509 PubMed citation Europe PMC
27323823 PubMed citation Europe PMC
27729622 PubMed citation Europe PMC
Last Modified
07 March 2018