CHEBI:132509 - HG-10-102-01

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ChEBI Name HG-10-102-01
Definition A monocarboxylic acid amide resulting from the formal condensation of the carboxy group of 4-{[5-chloro-4-(methylamino)pyrimidin-2-yl]amino}-3-methoxybenzoic acid with the amino group of morpholine. It is an inhibitor of leucine-rich repeat kinase 2 (LRRK2).
Stars This entity has been manually annotated by the ChEBI Team.
Submitter Margaret Duesbury
Supplier Information
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Formula C17H20ClN5O3
Net Charge 0
Average Mass 377.826
Monoisotopic Mass 377.12547
InChI InChI=1S/C17H20ClN5O3/c1-19-15-12(18)10-20-17(22-15)21-13-4-3-11(9-14(13)25-2)16(24)23-5-7-26-8-6-23/h3-4,9-10H,5-8H2,1-2H3,(H2,19,20,21,22)
Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): EC (non-specific serine/threonine protein kinase) inhibitor
An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of non-specific serine/threonine protein kinase (EC, a kinase enzyme involved in phosphorylation of hydroxy group of serine or threonine.
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ChEBI Ontology
Outgoing HG-10-102-01 (CHEBI:132509) has role EC (non-specific serine/threonine protein kinase) inhibitor (CHEBI:50925)
HG-10-102-01 (CHEBI:132509) is a aminopyrimidine (CHEBI:38338)
HG-10-102-01 (CHEBI:132509) is a aromatic ether (CHEBI:35618)
HG-10-102-01 (CHEBI:132509) is a monocarboxylic acid amide (CHEBI:29347)
HG-10-102-01 (CHEBI:132509) is a morpholines (CHEBI:38785)
HG-10-102-01 (CHEBI:132509) is a organochlorine compound (CHEBI:36683)
HG-10-102-01 (CHEBI:132509) is a secondary amino compound (CHEBI:50995)
Citations Waiting for Citations Types Sources
23066449 PubMed citation Europe PMC
23276252 PubMed citation Europe PMC
26824392 PubMed citation SUBMITTER
Last Modified
12 July 2016