CHEBI:131968 - tyrphostin B42

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ChEBI Name tyrphostin B42
ChEBI ID CHEBI:131968
Definition A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enoic acid with the amino group of benzylamine.
Stars This entity has been manually annotated by the ChEBI Team.
Submitter Ceri
Supplier Information
Download Molfile XML SDF
Formula C17H14N2O3
Net Charge 0
Average Mass 294.305
Monoisotopic Mass 294.100
InChI InChI=1S/C17H14N2O3/c18-10-14(8-13-6-7-15(20)16(21)9-13)17(22)19-11-12-4-2-1-3-5-12/h1-9,20-21H,11H2,(H,19,22)/b14-8+
InChIKey TUCIOBMMDDOEMM-RIYZIHGNSA-N
SMILES C=1(C=CC(=CC1O)/C=C(/C(NCC=2C=CC=CC2)=O)\C#N)O
Roles Classification
Chemical Role(s): antioxidant
A substance that opposes oxidation or inhibits reactions brought about by dioxygen or peroxides.
Biological Role(s): EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor
An EC 2.7.10.* (protein-tyrosine kinase) inhibitor that specifically blocks the action of non-specific protein-tyrosine kinase (EC 2.7.10.2).
STAT3 inhibitor
An inhibitor of signal transducer and activator of transcription 3 (STAT3)
apoptosis inducer
Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.
Application(s): anti-inflammatory agent
Any compound that has anti-inflammatory effects.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing tyrphostin B42 (CHEBI:131968) has role anti-inflammatory agent (CHEBI:67079)
tyrphostin B42 (CHEBI:131968) has role antioxidant (CHEBI:22586)
tyrphostin B42 (CHEBI:131968) has role apoptosis inducer (CHEBI:68495)
tyrphostin B42 (CHEBI:131968) has role EC 2.7.10.2 (non-specific protein-tyrosine kinase) inhibitor (CHEBI:76617)
tyrphostin B42 (CHEBI:131968) has role STAT3 inhibitor (CHEBI:87183)
tyrphostin B42 (CHEBI:131968) is a catechols (CHEBI:33566)
tyrphostin B42 (CHEBI:131968) is a enamide (CHEBI:51751)
tyrphostin B42 (CHEBI:131968) is a monocarboxylic acid amide (CHEBI:29347)
tyrphostin B42 (CHEBI:131968) is a nitrile (CHEBI:18379)
tyrphostin B42 (CHEBI:131968) is a secondary carboxamide (CHEBI:140325)
IUPAC Name
(2E)-N-benzyl-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide
Synonyms Sources
AG 490 SUBMITTER
AG-490 SUBMITTER
AG490 SUBMITTER
Registry Number Type Source
4323263 Reaxys Registry Number Reaxys
Citations Waiting for Citations Types Sources
10929036 PubMed citation Europe PMC
26190257 PubMed citation Europe PMC
26438799 PubMed citation Europe PMC
26487394 PubMed citation Europe PMC
26750536 PubMed citation Europe PMC
26919242 PubMed citation Europe PMC
27011172 PubMed citation Europe PMC
27044832 PubMed citation Europe PMC
27101310 PubMed citation Europe PMC
27107220 PubMed citation Europe PMC
27274711 PubMed citation Europe PMC
Last Modified
07 March 2018