CHEBI:131196 - OSU-03012

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ChEBI Name OSU-03012
ChEBI ID CHEBI:131196
Definition A member of the class of pyrazoles that is N-[4-(pyrazol-1-yl)phenyl]glycinamide in which the pyrazole ring is substituted at positions 3 and 5 by trifluoromethyl and phenanthrene-2-yl groups respectively.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C26H19F3N4O
Net Charge 0
Average Mass 460.451
Monoisotopic Mass 460.151
InChI InChI=1S/C26H19F3N4O/c27-26(28,29)24-14-23(33(32-24)20-10-8-19(9-11-20)31-25(34)15-30)18-7-12-22-17(13-18)6-5-16-3-1-2-4-21(16)22/h1-14H,15,30H2,(H,31,34)
InChIKey YULUCECVQOCQFQ-UHFFFAOYSA-N
SMILES C(=O)(NC1=CC=C(C=C1)N2N=C(C=C2C3=CC=4C(=C5C(=CC4)C=CC=C5)C=C3)C(F)(F)F)CN
Roles Classification
Biological Role(s): EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor
An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of non-specific serine/threonine protein kinase (EC 2.7.11.1), a kinase enzyme involved in phosphorylation of hydroxy group of serine or threonine.
apoptosis inducer
Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.
xenobiotic
A xenobiotic (Greek, xenos "foreign"; bios "life") is a compound that is foreign to a living organism. Principal xenobiotics include: drugs, carcinogens and various compounds that have been introduced into the environment by artificial means.
(via phenanthrenes )
antifungal drug
Any antifungal agent used to prevent or treat fungal infections in humans or animals.
(via antibiotic antifungal drug )
antifungal agent
An antimicrobial agent that destroys fungi by suppressing their ability to grow or reproduce.
(via antibiotic antifungal agent )
Application(s): antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
antifungal drug
Any antifungal agent used to prevent or treat fungal infections in humans or animals.
(via antibiotic antifungal drug )
View more via ChEBI Ontology
ChEBI Ontology
Outgoing OSU-03012 (CHEBI:131196) has role antineoplastic agent (CHEBI:35610)
OSU-03012 (CHEBI:131196) has role apoptosis inducer (CHEBI:68495)
OSU-03012 (CHEBI:131196) has role EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor (CHEBI:50925)
OSU-03012 (CHEBI:131196) is a antibiotic antifungal drug (CHEBI:87113)
OSU-03012 (CHEBI:131196) is a aromatic amide (CHEBI:62733)
OSU-03012 (CHEBI:131196) is a glycine derivative (CHEBI:24373)
OSU-03012 (CHEBI:131196) is a organofluorine compound (CHEBI:37143)
OSU-03012 (CHEBI:131196) is a phenanthrenes (CHEBI:25961)
OSU-03012 (CHEBI:131196) is a pyrazoles (CHEBI:26410)
IUPAC Name
N-{4-[5-(phenanthren-2-yl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]phenyl}glycinamide
Synonyms Sources
AR 12 ChemIDplus
AR-12 ChemIDplus
OSU 03012 ChemIDplus
PDK1 inhibitor AR-12 ChemIDplus
Manual Xref Database
OSU-03012 Wikipedia
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Registry Numbers Types Sources
11001693 Reaxys Registry Number Reaxys
742112-33-0 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
22354011 PubMed citation Europe PMC
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Last Modified
08 July 2016