CHEBI:116278 - lomefloxacin

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ChEBI Name lomefloxacin
ChEBI ID CHEBI:116278
Definition A fluoroquinolone antibiotic, used (generally as the hydrochloride salt) to treat bacterial infections including bronchitis and urinary tract infections. It is also used to prevent urinary tract infections prior to surgery.
Stars This entity has been manually annotated by the ChEBI Team.
Secondary ChEBI IDs CHEBI:6517
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Formula C17H19F2N3O3
Net Charge 0
Average Mass 351.34790
Monoisotopic Mass 351.139
InChI InChI=1S/C17H19F2N3O3/c1-3-21-8-11(17(24)25)16(23)10-6-12(18)15(13(19)14(10)21)22-5-4-20-9(2)7-22/h6,8-9,20H,3-5,7H2,1-2H3,(H,24,25)
InChIKey ZEKZLJVOYLTDKK-UHFFFAOYSA-N
SMILES CCn1cc(C(O)=O)c(=O)c2cc(F)c(N3CCNC(C)C3)c(F)c12
Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Bronsted acid
A molecular entity capable of donating a hydron to an acceptor (Bronsted base).
(via oxoacid )
Biological Role(s): antitubercular agent
A substance that kills or slows the growth of Mycobacterium tuberculosis and is used in the treatment of tuberculosis.
antimicrobial agent
A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans.
(via quinolone antibiotic )
(via heterocyclic antibiotic )
(via fluoroquinolone antibiotic )
Application(s): photosensitizing agent
A chemical compound that can be excited by light of a specific wavelength and subsequently transfer energy to a chosen reactant. This is commonly molecular oxygen within a cancer tissue, which is converted to (highly rective) singlet state oxygen. This rapidly reacts with any nearby biomolecules, ultimately killing the cancer cells.
antitubercular agent
A substance that kills or slows the growth of Mycobacterium tuberculosis and is used in the treatment of tuberculosis.
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ChEBI Ontology
Outgoing lomefloxacin (CHEBI:116278) has role antimicrobial agent (CHEBI:33281)
lomefloxacin (CHEBI:116278) has role antitubercular agent (CHEBI:33231)
lomefloxacin (CHEBI:116278) has role photosensitizing agent (CHEBI:47868)
lomefloxacin (CHEBI:116278) is a N-arylpiperazine (CHEBI:46848)
lomefloxacin (CHEBI:116278) is a fluoroquinolone antibiotic (CHEBI:87211)
lomefloxacin (CHEBI:116278) is a quinolinemonocarboxylic acid (CHEBI:26512)
lomefloxacin (CHEBI:116278) is a quinolone (CHEBI:23765)
lomefloxacin (CHEBI:116278) is a quinolone antibiotic (CHEBI:86324)
Incoming lomefloxacin hydrochloride (CHEBI:6518) has part lomefloxacin (CHEBI:116278)
IUPAC Name
1-ethyl-6,8-difluoro-7-(3-methylpiperazin-1-yl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
INN Source
lomefloxacin ChemIDplus
Synonyms Sources
(±)-1-ethyl-6,8-difluoro-1,4-dihydro-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid ChemIDplus
1,4-Dihydro-6,8-difluoro-1-ethyl-7-(3-methyl-1-piperazinyl)-4-oxo-3-quinolinecarboxylic acid ChemIDplus
LFLX KEGG DRUG
Lomefloxacine DrugBank
Lomefloxacino DrugBank
Lomefloxacinum DrugBank
Manual Xrefs Databases
1594 DrugCentral
C07078 KEGG COMPOUND
D02318 KEGG DRUG
DB00978 DrugBank
DE3433924 Patent
Lomefloxacin Wikipedia
LSM-5145 LINCS
US4528287 Patent
View more database links
Registry Numbers Types Sources
4210041 Beilstein Registry Number Beilstein
98079-51-7 CAS Registry Number KEGG COMPOUND
98079-51-7 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
11195849 PubMed citation Europe PMC
3134843 PubMed citation Europe PMC
3348607 PubMed citation Europe PMC
3476021 PubMed citation Europe PMC
Last Modified
22 February 2017