CHEBI:111762 - nordazepam

Main ChEBI Ontology Automatic Xrefs Reactions Pathways Models
ChEBI Name nordazepam
ChEBI ID CHEBI:111762
Definition A 1,4-benzodiazepinone having phenyl and chloro substituents at positions 5 and 7 respectively; it has anticonvulsant, anxiolytic, muscle relaxant and sedative properties but is used primarily in the treatment of anxiety.
Stars This entity has been manually annotated by the ChEBI Team.
Secondary ChEBI IDs CHEBI:7624
Supplier Information
Download Molfile XML SDF
Wikipedia License
Waiting for wikipedia content
Read full article at Wikipedia
Formula C15H11ClN2O
Net Charge 0
Average Mass 270.71400
Monoisotopic Mass 270.056
InChI InChI=1S/C15H11ClN2O/c16-11-6-7-13-12(8-11)15(17-9-14(19)18-13)10-4-2-1-3-5-10/h1-8H,9H2,(H,18,19)
InChIKey AKPLHCDWDRPJGD-UHFFFAOYSA-N
SMILES Clc1ccc2NC(=O)CN=C(c3ccccc3)c2c1
Metabolite of Species Details
Homo sapiens (NCBI:txid9606) See: DOI
Roles Classification
Biological Role(s): human metabolite
Any mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens).
GABA modulator
A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act.
(via benzodiazepine )
Application(s): anticonvulsant
A drug used to prevent seizures or reduce their severity.
sedative
A central nervous system depressant used to induce drowsiness or sleep or to reduce psychological excitement or anxiety.
GABA modulator
A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act.
(via benzodiazepine )
anxiolytic drug
Anxiolytic drugs are agents that alleviate anxiety, tension, and anxiety disorders, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing nordazepam (CHEBI:111762) has role anticonvulsant (CHEBI:35623)
nordazepam (CHEBI:111762) has role anxiolytic drug (CHEBI:35474)
nordazepam (CHEBI:111762) has role GABA modulator (CHEBI:50268)
nordazepam (CHEBI:111762) has role human metabolite (CHEBI:77746)
nordazepam (CHEBI:111762) has role sedative (CHEBI:35717)
nordazepam (CHEBI:111762) is a 1,4-benzodiazepinone (CHEBI:35500)
nordazepam (CHEBI:111762) is a organochlorine compound (CHEBI:36683)
IUPAC Name
7-chloro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one
INNs Sources
nordazepam ChemIDplus
nordazepamum ChemIDplus
Synonyms Sources
1-Demethyldiazepam ChemIDplus
7-Chloro-1,3-dihydro-5-phenyl-(2H)-1,4-benzodiazepin-2-one KEGG COMPOUND
7-Chloro-1,3-dihydro-5-phenyl-2H-1,4-benzodiazepin-2-one ChemIDplus
7-Chloro-5-phenyl-1,3-dihydro-2H-1,4-benzodiazepin-2-one NIST Chemistry WebBook
Chlordesmethyldiazepam NIST Chemistry WebBook
Chlordesmethyldiazepam ChemIDplus
Dealkylprazepam NIST Chemistry WebBook
Desmethyldiazepam KEGG COMPOUND
Desmethyldiazepam ChemIDplus
N-Demethyldiazepam ChemIDplus
N-Deoxydemoxepam ChemIDplus
N-Desmethyldiazepam ChemIDplus
N1-Desmethyldiazepam NIST Chemistry WebBook
Nordiazepam ChemIDplus
Norprazepam ChemIDplus
Manual Xrefs Databases
816 DrugCentral
BE620020 Patent
C07486 KEGG COMPOUND
D08283 KEGG DRUG
DE1136709 Patent
Desmethyldiazepam Wikipedia
US3051701 Patent
US3202699 Patent
View more database links
Registry Numbers Types Sources
1088-11-5 CAS Registry Number ChemIDplus
1088-11-5 CAS Registry Number NIST Chemistry WebBook
751823 Reaxys Registry Number Reaxys
Citations Waiting for Citations Types Sources
16622 PubMed citation Europe PMC
19604 PubMed citation Europe PMC
360230 PubMed citation Europe PMC
364005 PubMed citation Europe PMC
367407 PubMed citation Europe PMC
4953859 PubMed citation Europe PMC
Last Modified
22 February 2017