CHEBI:110423 - clodronic acid

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ChEBI Name clodronic acid
Definition An organochlorine compound that is methylene chloride in which both hydrogens are replaced by phosphonic acid groups. It inhibits bone resorption and soft tissue calcification, and is used (often as the disodium salt tetrahydrate) as an adjunct in the treatment of severe hypercalcaemia associated with malignancy, and in the management of osteolytic lesions and bone pain associated with skeletal metastases.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula CH4Cl2O6P2
Net Charge 0
Average Mass 244.89200
Monoisotopic Mass 243.886
InChI InChI=1S/CH4Cl2O6P2/c2-1(3,10(4,5)6)11(7,8)9/h(H2,4,5,6)(H2,7,8,9)
SMILES OP(O)(=O)C(Cl)(Cl)P(O)(O)=O
Roles Classification
Application(s): bone density conservation agent
An agent that inhibits bone resorption and/or favor bone mineralization and bone regeneration. Used to heal bone fractures and to treat bone diseases such as osteopenia and osteoporosis.
antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
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ChEBI Ontology
Outgoing clodronic acid (CHEBI:110423) has role antineoplastic agent (CHEBI:35610)
clodronic acid (CHEBI:110423) has role bone density conservation agent (CHEBI:50646)
clodronic acid (CHEBI:110423) is a 1,1-bis(phosphonic acid) (CHEBI:77383)
clodronic acid (CHEBI:110423) is a one-carbon compound (CHEBI:64708)
clodronic acid (CHEBI:110423) is a organochlorine compound (CHEBI:36683)
clodronic acid (CHEBI:110423) is conjugate acid of clondronate(2−) (CHEBI:59585)
Incoming clondronate(2−) (CHEBI:59585) is conjugate base of clodronic acid (CHEBI:110423)
(dichloromethanediyl)bis(phosphonic acid)
INNs Sources
acide clodronique ChemIDplus
acido clodronico ChemIDplus
acidum clodronicum ChemIDplus
clodronic acid ChemIDplus
Synonyms Sources
(Dichloro-phosphono-methyl)-phosphonic acid ChEMBL
(dichloromethylene)bisphosphonic acid ChEBI
(dichloromethylene)diphosphonic acid ChEBI
clodronate ChemIDplus
clodronsaeure ChemIDplus
dichloromethylene-1,1-bisphosphonic acid ChEBI
dichloromethylene-1,1-diphosphonic acid ChEBI
dichloromethylidene diphosphonate ChemIDplus
Manual Xrefs Databases
690 DrugCentral
BE672205 Patent
DB00720 DrugBank
View more database links
Registry Numbers Types Sources
10596-23-3 CAS Registry Number ChemIDplus
1876367 Beilstein Registry Number Beilstein
Citations Waiting for Citations Types Sources
15658873 PubMed citation ChEMBL
7818726 PubMed citation ChEMBL
8421279 PubMed citation ChEMBL
Last Modified
22 February 2017