A β-caryophyllene in which the stereocentre adjacent to the exocyclic double bond has S configuration while the remaining stereocentre has R configuration. It is the most commonly occurring form of β-caryophyllene, occurring in many essential oils, particularly oil of cloves.
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An anti-inflammatory drug that is not a steroid. In addition to anti-inflammatory actions, non-steroidal anti-inflammatory drugs have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins.
Caryophyllene is a constituent of many essential oils, particularly oil of cloves, hemp, rosemary and hops, it is usually found as a mixture with isocaryophyllene (the cis-couble bond isomer) and α-humulene (also known as α-caryophyllene, a ring-openend isomer). The presence of the cyclobutane ring is noteworthyl - it is an uncommon feature in natural products.