CHEBI:101854 - talarozole

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ChEBI Name talarozole
ChEBI ID CHEBI:101854
Definition A racemate comprising equimolar amounts of (R)- and (S)-talarozole. It is used for the treatment of keratinization disorders, psoriasis and acne.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C21H23N5S
Net Charge 0
Average Mass 377.508
Monoisotopic Mass 377.16742
Roles Classification
Biological Role(s): P450 inhibitor
An enzyme inhibitor that interferes with the activity of cytochrome P450 involved in catalysis of organic substances.
Application(s): keratolytic drug
A drug that softens, separates, and causes desquamation of the cornified epithelium or horny layer of skin. Keratolytic drugs are used to expose mycelia of infecting fungi or to treat corns, warts, and certain other skin diseases.
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ChEBI Ontology
Outgoing talarozole (CHEBI:101854) has part (R)-talarozole (CHEBI:102030)
talarozole (CHEBI:101854) has part (S)-talarozole (CHEBI:102131)
talarozole (CHEBI:101854) has role keratolytic drug (CHEBI:50176)
talarozole (CHEBI:101854) has role P450 inhibitor (CHEBI:50183)
talarozole (CHEBI:101854) is a racemate (CHEBI:60911)
IUPAC Name
rac-N-{4-[2-ethyl-1-(1H-1,2,4-triazol-1-yl)butyl]phenyl}-1,3-benzothiazol-2-amine
INN Source
talarozole KEGG DRUG
Synonyms Sources
(±)-talarozole ChEBI
(RS)-talarozole ChEBI
N-(4-((1RS)-2-Ethyl-1-(1H-1,2,4-triazol-1-yl)butyl)phenyl)benzothiazol-2-amine ChemIDplus
N-(4-(2-Ethyl-1-(1H-1,2,4-triazol-1-yl)butyl)phenyl)-2-benzothiazolamine ChemIDplus
R 115866 ChemIDplus
R115866 ChemIDplus
Brand Name Source
Rambazole KEGG DRUG
Manual Xrefs Databases
D09385 KEGG DRUG
Talarozole Wikipedia
View more database links
Registry Numbers Types Sources
11737106 Reaxys Registry Number Reaxys
201410-53-9 CAS Registry Number ChemIDplus
201410-53-9 CAS Registry Number KEGG DRUG
Citations Waiting for Citations Types Sources
19120344 PubMed citation Europe PMC
26921399 PubMed citation Europe PMC
Last Modified
01 April 2016
General Comment
2016-04-01 This is the entry for the racemic entity. There are separate entries for the individual enantiomers [(R)-talarozole and (S)-talarozole] and for the entity with unspecified stereochemistry (N-{4-[2-ethyl-1-(1H-1,2,4-triazol-1-yl)butyl]phenyl}-1,3-benzothiazol-2-amine).