CHEBI:101096 - ethoxzolamide

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ChEBI Name ethoxzolamide
ChEBI ID CHEBI:101096
Definition 1,3-Benzothiazole substituted a sulfonamide and an ethoxy group at positions 2 and 6, respectively. A carbonic anhydrase inhibitor, it has been used in the treatment of glaucoma, and as a diuretic.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C9H10N2O3S2
Net Charge 0
Average Mass 258.31700
InChI InChI=1S/C9H10N2O3S2/c1-2-14-6-3-4-7-8(5-6)15-9(11-7)16(10,12)13/h3-5H,2H2,1H3,(H2,10,12,13)
InChIKey OUZWUKMCLIBBOG-UHFFFAOYSA-N
SMILES CCOc1ccc2nc(sc2c1)S(N)(=O)=O
Roles Classification
Biological Role(s): EC 4.2.1.1 (carbonic anhydrase) inhibitor
An EC 4.2.1.* (hydro-lyases) inhibitor that interferes with the action of carbonic anhydrase (EC 4.2.1.1). Such compounds reduce the secretion of H+ ions by the proximal kidney tubule.
Application(s): diuretic
An agent that promotes the excretion of urine through its effects on kidney function.
antiglaucoma drug
Any drug which can be used to prevent or alleviate glaucoma, a disease in which the optic nerve is damaged, resulting in progressive, irreversible loss of vision. It is often, though not always, associated with increased pressure of the fluid in the eye.
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ChEBI Ontology
Outgoing ethoxzolamide (CHEBI:101096) has role antiglaucoma drug (CHEBI:39456)
ethoxzolamide (CHEBI:101096) has role diuretic (CHEBI:35498)
ethoxzolamide (CHEBI:101096) has role EC 4.2.1.1 (carbonic anhydrase) inhibitor (CHEBI:23018)
ethoxzolamide (CHEBI:101096) is a benzothiazoles (CHEBI:37947)
ethoxzolamide (CHEBI:101096) is a sulfonamide (CHEBI:35358)
IUPAC Name
6-ethoxy-1,3-benzothiazole-2-sulfonamide
Synonyms Sources
6-ethoxy-2-benzothiazolesulfonamide ChemIDplus
6-Ethoxy-benzothiazole-2-sulfonic acid amide ChEMBL
6-ethoxybenzothiazole-2-sulfonamide NIST Chemistry WebBook
ethoxazolamide ChEMBL
ethoxyzolamide ChemIDplus
ETHOXZOLAMIDE ChEMBL
Database Links Databases
D02441 KEGG DRUG
DB00311 DrugBank
Ethoxzolamide Wikipedia
GB795174 Patent
US2868800 Patent
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Registry Numbers Types Sources
452-35-7 CAS Registry Number ChemIDplus
452-35-7 CAS Registry Number NIST Chemistry WebBook
452-35-7 CAS Registry Number KEGG DRUG
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Last Modified
07 October 2010