CHEBI:101085 - diclofenamide

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ChEBI Name diclofenamide
ChEBI ID CHEBI:101085
Definition A sulfonamide that is benzene-1,3-disulfonamide in which the hydrogens at positions 4 and 5 are substituted by chlorine. An oral carbonic anhydrase inhibitor, it partially suppresses the secretion (inflow) of aqueous humor in the eye and so reduces intraocular pressure. It is used for the treatment of glaucoma.
Stars This entity has been manually annotated by the ChEBI Team.
Secondary ChEBI IDs CHEBI:47477, CHEBI:4505
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Formula C6H6Cl2N2O4S2
Net Charge 0
Average Mass 305.15900
Monoisotopic Mass 303.915
InChI InChI=1S/C6H6Cl2N2O4S2/c7-4-1-3(15(9,11)12)2-5(6(4)8)16(10,13)14/h1-2H,(H2,9,11,12)(H2,10,13,14)
InChIKey GJQPMPFPNINLKP-UHFFFAOYSA-N
SMILES NS(=O)(=O)c1cc(Cl)c(Cl)c(c1)S(N)(=O)=O
Roles Classification
Biological Role(s): EC 4.2.1.1 (carbonic anhydrase) inhibitor
An EC 4.2.1.* (hydro-lyases) inhibitor that interferes with the action of carbonic anhydrase (EC 4.2.1.1). Such compounds reduce the secretion of H+ ions by the proximal kidney tubule.
Application(s): antiglaucoma drug
Any drug which can be used to prevent or alleviate glaucoma, a disease in which the optic nerve is damaged, resulting in progressive, irreversible loss of vision. It is often, though not always, associated with increased pressure of the fluid in the eye.
ophthalmology drug
Any compound used for the treatment of eye conditions or eye diseases.
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ChEBI Ontology
Outgoing diclofenamide (CHEBI:101085) has role antiglaucoma drug (CHEBI:39456)
diclofenamide (CHEBI:101085) has role EC 4.2.1.1 (carbonic anhydrase) inhibitor (CHEBI:23018)
diclofenamide (CHEBI:101085) has role ophthalmology drug (CHEBI:66981)
diclofenamide (CHEBI:101085) is a dichlorobenzene (CHEBI:23697)
diclofenamide (CHEBI:101085) is a sulfonamide (CHEBI:35358)
IUPAC Name
4,5-dichlorobenzene-1,3-disulfonamide
INNs Sources
dichlofenamide ChEBI
diclofenamida ChemIDplus
diclofenamidum ChemIDplus
Synonyms Sources
1,3-disulfamoyl-4,5-dichlorobenzene ChemIDplus
1,3-disulfamyl-4,5-dichlorobenzene ChemIDplus
3,4-dichloro-5-sulfamylbenzenesulfonamide ChemIDplus
4,5-dichloro-1,3-benzenedisulfonamide NIST Chemistry WebBook
4,5-dichloro-1,3-disulfamoylbenzene ChemIDplus
4,5-dichloro-benzene-1,3-disulfonic acid diamide ChEMBL
4,5-dichloro-m-benzenedisulfonamide ChemIDplus
4,5-DICHLOROBENZENE-1,3-DISULFONAMIDE PDBeChem
Dichlorophenamide ChEMBL
dichlorophenamide ChEMBL
Dichlorphenamide KEGG COMPOUND
DICHLORPHENAMIDE ChEMBL
dichlorphenamide ChEMBL
Diclofenamide KEGG COMPOUND
DICLOFENAMIDE ChEMBL
Manual Xrefs Databases
864 DrugCentral
C07459 KEGG COMPOUND
D00518 KEGG DRUG
DB01144 DrugBank
Dichlorphenamide Wikipedia
I7A PDBeChem
LSM-3602 LINCS
US2835702 Patent
View more database links
Registry Numbers Types Sources
120-97-8 CAS Registry Number KEGG COMPOUND
120-97-8 CAS Registry Number NIST Chemistry WebBook
120-97-8 CAS Registry Number ChemIDplus
2703329 Beilstein Registry Number Beilstein
Last Modified
22 February 2017