CHEBI:90536 - PQIP

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Definition A member of the class of imidazopyrazines that is imidazo[1,5-a]pyrazin-8-amine carrying additional 2-phenylquinolin-7-yl and 3-(4-methylpiperazin-1-yl)cyclobutyl groups at positions 1 and 3 respectively. It is an inhibitor of insulin growth factor 1 receptor (IGF-1 receptor, IGFR1R) tyrosine kinase.
Stars This entity has been manually annotated by the ChEBI Team.
Submitter Matthias Ziehm
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Formula C30H31N7
Net Charge 0
Average Mass 489.615
Monoisotopic Mass 489.26409
InChI InChI=1S/C30H31N7/c1-35-13-15-36(16-14-35)24-17-23(18-24)30-34-27(28-29(31)32-11-12-37(28)30)22-8-7-21-9-10-25(33-26(21)19-22)20-5-3-2-4-6-20/h2-12,19,23-24H,13-18H2,1H3,(H2,31,32)/t23-,24+
SMILES NC1=NC=CN2C1=C(N=C2[C@@]3(C[C@@](C3)(N4CCN(CC4)C)[H])[H])C5=CC6=NC(C7=CC=CC=C7)=CC=C6C=C5
Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): EC (receptor protein-tyrosine kinase) inhibitor
An EC 2.7.10.* (protein-tyrosine kinase) inhibitor that interferes with the action of receptor protein-tyrosine kinase (EC
insulin-like growth factor receptor 1 antagonist
An antagonist at the insulin-like growth factor receptor 1.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing PQIP (CHEBI:90536) has role EC (receptor protein-tyrosine kinase) inhibitor (CHEBI:62434)
PQIP (CHEBI:90536) has role insulin-like growth factor receptor 1 antagonist (CHEBI:75252)
PQIP (CHEBI:90536) is a N-alkylpiperazine (CHEBI:46845)
PQIP (CHEBI:90536) is a aromatic amine (CHEBI:33860)
PQIP (CHEBI:90536) is a imidazopyrazine (CHEBI:37847)
PQIP (CHEBI:90536) is a primary amino compound (CHEBI:50994)
PQIP (CHEBI:90536) is a quinolines (CHEBI:26513)
Manual Xref Database
D94 PDBeChem
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Registry Numbers Types Sources
12423292 Reaxys Registry Number Reaxys
12923638 Reaxys Registry Number Reaxys
Citations Waiting for Citations Types Sources
17671083 PubMed citation Europe PMC
18566589 PubMed citation Europe PMC
20943761 PubMed citation Europe PMC
21850397 PubMed citation Europe PMC
22101930 PubMed citation Europe PMC
23239200 PubMed citation Europe PMC
Last Modified
14 July 2016