CHEBI:87283 - PF-670462 free base

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ChEBI Name PF-670462 free base
Definition A member of the class of imidazoles that is 1H-imidazole which is substituted at positions 1, 4, and 5 by cyclohexyl, p-fluorophenyl, and 2-aminopyrimidin-4-yl groups, respectively. It is a selective inhibitor of the δ- and ε-isoforms of casein kinase 1 (CK1δ and CK1ε).
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
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Formula C19H20FN5
Net Charge 0
Average Mass 337.39400
Monoisotopic Mass 337.17027
InChI InChI=1S/C19H20FN5/c20-14-8-6-13(7-9-14)17-18(16-10-11-22-19(21)24-16)25(12-23-17)15-4-2-1-3-5-15/h6-12,15H,1-5H2,(H2,21,22,24)
SMILES Nc1nccc(n1)-c1c(ncn1C1CCCCC1)-c1ccc(F)cc1
Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): EC (non-specific serine/threonine protein kinase) inhibitor
An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of non-specific serine/threonine protein kinase (EC, a kinase enzyme involved in phosphorylation of hydroxy group of serine or threonine.
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ChEBI Ontology
Outgoing PF-670462 free base (CHEBI:87283) has role EC (non-specific serine/threonine protein kinase) inhibitor (CHEBI:50925)
PF-670462 free base (CHEBI:87283) is a aminopyrimidine (CHEBI:38338)
PF-670462 free base (CHEBI:87283) is a imidazoles (CHEBI:24780)
PF-670462 free base (CHEBI:87283) is a monofluorobenzenes (CHEBI:83575)
PF-670462 free base (CHEBI:87283) is conjugate base of PF-670462 free base(2+) (CHEBI:87284)
Incoming PF-670462 free base(2+) (CHEBI:87284) is conjugate acid of PF-670462 free base (CHEBI:87283)
Synonyms Sources
4-(1-cyclohexyl-4-(4-fluorophenyl)-1H-imidazol-5-yl)-2-pyrimidinamine ChemIDplus
free base of PF-670462 ChEBI
Registry Numbers Types Sources
11152378 Reaxys Registry Number Reaxys
950980-98-0 CAS Registry Number ChemIDplus
Last Modified
03 August 2015