CHEBI:6757 - mephenytoin

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ChEBI Name mephenytoin
ChEBI ID CHEBI:6757
Definition An imidazolidine-2,4-dione (hydantoin) in which the imidazolidine nucleus carries a methyl group at N-3 and has ethyl and phenyl substituents at C-5. An anticonvulsant, it is no longer available in the USA or the UK but is still studied largely because of its interesting hydroxylation polymorphism.
Stars This entity has been manually annotated by the ChEBI Team.
Secondary ChEBI IDs CHEBI:91914
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Formula C12H14N2O2
Net Charge 0
Average Mass 218.252
Monoisotopic Mass 218.106
InChI InChI=1S/C12H14N2O2/c1-3-12(9-7-5-4-6-8-9)10(15)14(2)11(16)13-12/h4-8H,3H2,1-2H3,(H,13,16)
InChIKey GMHKMTDVRCWUDX-UHFFFAOYSA-N
SMILES CCC1(C(=O)N(C(=O)N1)C)C2=CC=CC=C2
Roles Classification
Application(s): anticonvulsant
A drug used to prevent seizures or reduce their severity.
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ChEBI Ontology
Outgoing mephenytoin (CHEBI:6757) has role anticonvulsant (CHEBI:35623)
mephenytoin (CHEBI:6757) is a imidazolidine-2,4-dione (CHEBI:24628)
IUPAC Name
5-ethyl-3-methyl-5-phenylimidazolidine-2,4-dione
INNs Sources
mefenitoína WHO MedNet
mephenytoin KEGG DRUG
méphénytoïne WHO MedNet
mephenytoinum WHO MedNet
Synonyms Sources
DL-Mephenytoin DrugCentral
methylphenetoin DrugCentral
phenylethylmethylhydantoin DrugCentral
Manual Xrefs Databases
1695 DrugCentral
D00375 KEGG DRUG
LSM-1852 LINCS
Mephenytoin Wikipedia
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Registry Numbers Types Sources
17282 Reaxys Registry Number Reaxys
50-12-4 CAS Registry Number DrugCentral
Citations Waiting for Citations Types Sources
11422005 PubMed citation Europe PMC
15282764 PubMed citation Europe PMC
25797720 PubMed citation Europe PMC
29438107 PubMed citation Europe PMC
Last Modified
20 June 2018