CHEBI:66243 - TMC-86B

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ChEBI Name TMC-86B
Definition An epoxide that is oxiran-2-ylmethanol which is acylated at position 2 by N-(6-hydroxy-6-methylheptanoyl)-L-seryl-4-methylidenenorvalinyl group. It is a proteasome inhibitor isolated from Streptomyces.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
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Formula C20H34N2O7
Net Charge 0
Average Mass 414.49320
Monoisotopic Mass 414.23660
InChI InChI=1S/C20H34N2O7/c1-13(2)9-14(17(26)20(11-24)12-29-20)22-18(27)15(10-23)21-16(25)7-5-6-8-19(3,4)28/h14-15,23-24,28H,1,5-12H2,2-4H3,(H,21,25)(H,22,27)/t14?,15-,20?/m0/s1
Metabolite of Species Details
Streptomyces sp. (NCBI:txid1931) of strain TC 1084 See: PubMed
Roles Classification
Biological Role(s): bacterial metabolite
Any prokaryotic metabolite produced during a metabolic reaction in bacteria.
antimicrobial agent
A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans.
Application(s): proteasome inhibitor
A drug that blocks the action of proteasomes, cellular complexes that break down proteins.
antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing TMC-86B (CHEBI:66243) has role antimicrobial agent (CHEBI:33281)
TMC-86B (CHEBI:66243) has role antineoplastic agent (CHEBI:35610)
TMC-86B (CHEBI:66243) has role bacterial metabolite (CHEBI:76969)
TMC-86B (CHEBI:66243) has role proteasome inhibitor (CHEBI:52726)
TMC-86B (CHEBI:66243) is a epoxide (CHEBI:32955)
TMC-86B (CHEBI:66243) is a ketone (CHEBI:17087)
TMC-86B (CHEBI:66243) is a monocarboxylic acid amide (CHEBI:29347)
TMC-86B (CHEBI:66243) is a primary alcohol (CHEBI:15734)
Registry Number Type Source
8518741 Reaxys Registry Number Reaxys
Citations Waiting for Citations Types Sources
10695669 PubMed citation Europe PMC
10724010 PubMed citation Europe PMC
Last Modified
06 March 2014