CHEBI:66111 - jaspamide H

Main ChEBI Ontology Automatic Xrefs Reactions Pathways Models
ChEBI Name jaspamide H
Definition A cyclodepsipeptide isolated from Jaspis splendens. A derivative of jaspamide, it has been shown to exhibit cytotoxic and microfilament disruption activity.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
Download Molfile XML SDF
Formula C35H43BrN4O6
Net Charge 0
Average Mass 695.64300
Monoisotopic Mass 694.237
InChI InChI=1S/C35H43BrN4O6/c1-20-9-8-10-22(3)46-31(42)19-29(24-13-15-25(41)16-14-24)39-34(44)30(18-27-26-11-6-7-12-28(26)38-32(27)36)40(5)35(45)23(4)37-33(43)21(2)17-20/h6-7,9,11-16,21-23,29-30,38,41H,8,10,17-19H2,1-5H3,(H,37,43)(H,39,44)/b20-9+/t21-,22-,23-,29+,30+/m0/s1
SMILES [H]C1C[C@H](C)OC(=O)C[C@@H](NC(=O)[C@@H](Cc2c(Br)[nH]c3ccccc23)N(C)C(=O)[C@H](C)NC(=O)[C@@H](C)C\C(C)=C\1)c1ccc(O)cc1
Metabolite of Species Details
Jaspis sp.endens (WORMS:169842) See: DOI
Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): marine metabolite
Any metabolite produced during a metabolic reaction in marine macro- and microorganisms.
actin polymerisation inhibitor
Any substance that inhibits the polymerisation of the protein actin.
animal metabolite
Any eukaryotic metabolite produced during a metabolic reaction in animals that include diverse creatures from sponges, insects to mammals.
Application(s): antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing jaspamide H (CHEBI:66111) has role actin polymerisation inhibitor (CHEBI:70728)
jaspamide H (CHEBI:66111) has role animal metabolite (CHEBI:75767)
jaspamide H (CHEBI:66111) has role antineoplastic agent (CHEBI:35610)
jaspamide H (CHEBI:66111) has role marine metabolite (CHEBI:76507)
jaspamide H (CHEBI:66111) is a cyclodepsipeptide (CHEBI:35213)
jaspamide H (CHEBI:66111) is a macrocycle (CHEBI:51026)
jaspamide H (CHEBI:66111) is a organobromine compound (CHEBI:37141)
Last Modified
13 April 2015
General Comment
2013-03-06 Tetrahedron (2008),64, 7127-7130.