CHEBI:64323 - memantine hydrochloride

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ChEBI Name memantine hydrochloride
Definition A hydrochloride obtained by reaction of memantine with one equivalent of hydrochloric acid. A low to moderate affinity uncompetitive (open-channel); NMDA receptor antagonist which binds preferentially to the NMDA receptor-operated cation channels.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
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Formula C12H22ClN
Net Charge 0
Average Mass 215.76300
Monoisotopic Mass 215.14408
InChI InChI=1S/C12H21N.ClH/c1-10-3-9-4-11(2,6-10)8-12(13,5-9)7-10;/h9H,3-8,13H2,1-2H3;1H
Roles Classification
Biological Role(s): dopaminergic agent
A drug used for its effects on dopamine receptors, on the life cycle of dopamine, or on the survival of dopaminergic neurons.
NMDA receptor antagonist
Any substance that inhibits the action of N-methyl-D-aspartate (NMDA) receptors. They tend to induce a state known as dissociative anesthesia, marked by catalepsy, amnesia, and analgesia, while side effects can include hallucinations, nightmares, and confusion. Due to their psychotomimetic effects, many NMDA receptor antagonists are used as recreational drugs.
Application(s): antidepressant
Antidepressants are mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions.
antiparkinson drug
A drug used in the treatment of Parkinson's disease.
dopaminergic agent
A drug used for its effects on dopamine receptors, on the life cycle of dopamine, or on the survival of dopaminergic neurons.
neuroprotective agent
Any compound that can be used for the treatment of neurodegenerative disorders.
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ChEBI Ontology
Outgoing memantine hydrochloride (CHEBI:64323) has part memantinium(1+) (CHEBI:64325)
memantine hydrochloride (CHEBI:64323) has role antidepressant (CHEBI:35469)
memantine hydrochloride (CHEBI:64323) has role antiparkinson drug (CHEBI:48407)
memantine hydrochloride (CHEBI:64323) has role dopaminergic agent (CHEBI:48560)
memantine hydrochloride (CHEBI:64323) has role neuroprotective agent (CHEBI:63726)
memantine hydrochloride (CHEBI:64323) has role NMDA receptor antagonist (CHEBI:60643)
memantine hydrochloride (CHEBI:64323) is a hydrochloride (CHEBI:36807)
3,5-dimethyladamantan-1-amine hydrochloride
Synonyms Sources
1-Amino-3,5-dimethyladamantane hydrochloride ChemIDplus
3,5-Dimethyl-1-adamantanamine hydrochloride ChemIDplus
3,5-dimethyladamantan-1-aminium chloride IUPAC
3,5-dimethyltricyclo(,7)decan-1-amine hydrochloride ChemIDplus
Memantine HCl ChemIDplus
memantine.HCl ChEBI
Brand Name Source
Manual Xrefs Databases
DB01043 DrugBank
US2011282100 Patent
WO2011125062 Patent
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Registry Numbers Types Sources
41100-52-1 CAS Registry Number ChemIDplus
41100-52-1 CAS Registry Number KEGG DRUG
6573843 Reaxys Registry Number Reaxys
Citations Waiting for Citations Types Sources
19196860 PubMed citation Europe PMC
20013176 PubMed citation Europe PMC
20703320 PubMed citation Europe PMC
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Last Modified
29 March 2012