CHEBI:64159 - 2-methyl-6-(phenylethynyl)pyridine

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ChEBI Name 2-methyl-6-(phenylethynyl)pyridine
Definition A methylpyridine that coinsists of 2-methylp[yridine bearing an additional phenylethynyl group at position 6. Potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype (IC50 = 36 nM) and a positive allosteric modulator at mGlu4 receptors. Centrally active following systemic administration in vivo. Reverses mechanical hyperalgesia in the inflamed rat hind paw.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C14H11N
Net Charge 0
Average Mass 193.24380
Monoisotopic Mass 193.08915
InChI InChI=1S/C14H11N/c1-12-6-5-9-14(15-12)11-10-13-7-3-2-4-8-13/h2-9H,1H3
SMILES Cc1cccc(n1)C#Cc1ccccc1
Roles Classification
Biological Role(s): metabotropic glutamate receptor antagonist
An antagonist at the metabotropic glutamate receptor.
Application(s): anxiolytic drug
Anxiolytic drugs are agents that alleviate anxiety, tension, and anxiety disorders, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions.
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ChEBI Ontology
Outgoing 2-methyl-6-(phenylethynyl)pyridine (CHEBI:64159) has parent hydride acetylene (CHEBI:27518)
2-methyl-6-(phenylethynyl)pyridine (CHEBI:64159) has role anxiolytic drug (CHEBI:35474)
2-methyl-6-(phenylethynyl)pyridine (CHEBI:64159) has role metabotropic glutamate receptor antagonist (CHEBI:63963)
2-methyl-6-(phenylethynyl)pyridine (CHEBI:64159) is a acetylenic compound (CHEBI:73474)
2-methyl-6-(phenylethynyl)pyridine (CHEBI:64159) is a methylpyridines (CHEBI:25340)
2-methyl-6-(phenylethynyl)pyridine (CHEBI:64159) is conjugate base of 2-methyl-6-(phenylethynyl)pyridinium(1+) (CHEBI:64160)
Incoming 2-methyl-6-(phenylethynyl)pyridinium(1+) (CHEBI:64160) is conjugate acid of 2-methyl-6-(phenylethynyl)pyridine (CHEBI:64159)
Synonyms Sources
6-Methyl-2-(phenylethynyl)pyridine ChemIDplus
MPEP ChemIDplus
Manual Xref Database
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Registry Numbers Types Sources
140513 Reaxys Registry Number Reaxys
219911-35-0 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
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Last Modified
25 February 2016