CHEBI:64158 - 2-methyl-6-(phenylethynyl)pyridine hydrochloride

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ChEBI Name 2-methyl-6-(phenylethynyl)pyridine hydrochloride
Definition A hydrochloride salt obtained by reaction of 2-methyl-6-(phenylethynyl)pyridine with one equivalent of hydrochloric acid. Potent and highly selective non-competitive antagonist at the mGlu5 receptor subtype (IC50 = 36 nM) and a positive allosteric modulator at mGlu4 receptors. Centrally active following systemic administration in vivo. Reverses mechanical hyperalgesia in the inflamed rat hind paw.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C14H12ClN
Net Charge 0
Average Mass 229.70500
Monoisotopic Mass 229.06583
InChI InChI=1S/C14H11N.ClH/c1-12-6-5-9-14(15-12)11-10-13-7-3-2-4-8-13;/h2-9H,1H3;1H
SMILES Cl.Cc1cccc(n1)C#Cc1ccccc1
Roles Classification
Biological Role(s): metabotropic glutamate receptor antagonist
An antagonist at the metabotropic glutamate receptor.
Application(s): anxiolytic drug
Anxiolytic drugs are agents that alleviate anxiety, tension, and anxiety disorders, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions.
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ChEBI Ontology
Outgoing 2-methyl-6-(phenylethynyl)pyridine hydrochloride (CHEBI:64158) has part 2-methyl-6-(phenylethynyl)pyridinium(1+) (CHEBI:64160)
2-methyl-6-(phenylethynyl)pyridine hydrochloride (CHEBI:64158) has role anxiolytic drug (CHEBI:35474)
2-methyl-6-(phenylethynyl)pyridine hydrochloride (CHEBI:64158) has role metabotropic glutamate receptor antagonist (CHEBI:63963)
2-methyl-6-(phenylethynyl)pyridine hydrochloride (CHEBI:64158) is a hydrochloride (CHEBI:36807)
2-methyl-6-(phenylethynyl)pyridine hydrochloride
Synonyms Sources
2-methyl-6-(phenylethynyl)pyridinium chloride IUPAC
6-methyl-2-(phenylethynyl)pyridine hydrochloride ChEBI
6-methyl-2-(phenylethynyl)pyridinium chloride ChEBI
MPEP hydrochloride ChEBI
Registry Number Type Source
9652435 Reaxys Registry Number Reaxys
Citation Waiting for Citations Type Source
20347777 PubMed citation Europe PMC
Last Modified
12 March 2012