CHEBI:3762 - dipotassium clorazepate

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ChEBI Name dipotassium clorazepate
ChEBI ID CHEBI:3762
Definition The compound of monopotassium clorazepate with potassium hydroxide. It is used for the management of anxiety disorders, for the short-term relief of anxiety, as adjunctive therapy in the management of epilepsy, and for the symptomatic relief of acute alcohol withdrawal.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
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Formula C16H11ClK2N2O4
Net Charge 0
Average Mass 408.91900
Monoisotopic Mass 407.968
InChI InChI=1S/C16H11ClN2O3.2K.H2O/c17-10-6-7-12-11(8-10)13(9-4-2-1-3-5-9)19-14(16(21)22)15(20)18-12;;;/h1-8,14H,(H,18,20)(H,21,22);;;1H2/q;2*+1;/p-2
InChIKey QCHSEDTUUKDTIG-UHFFFAOYSA-L
SMILES [OH-].[K+].[K+].[O-]C(=O)C1N=C(c2ccccc2)c2cc(Cl)ccc2NC1=O
Roles Classification
Biological Role(s): GABA modulator
A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act.
Application(s): prodrug
A compound that, on administration, must undergo chemical conversion by metabolic processes before becoming the pharmacologically active drug for which it is a prodrug.
anticonvulsant
A drug used to prevent seizures or reduce their severity.
anxiolytic drug
Anxiolytic drugs are agents that alleviate anxiety, tension, and anxiety disorders, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions.
GABA modulator
A substance that does not act as agonist or antagonist but does affect the gamma-aminobutyric acid receptor-ionophore complex. GABA-A receptors appear to have at least three allosteric sites at which modulators act: a site at which benzodiazepines act by increasing the opening frequency of gamma-aminobutyric acid-activated chloride channels; a site at which barbiturates act to prolong the duration of channel opening; and a site at which some steroids may act.
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ChEBI Ontology
Outgoing dipotassium clorazepate (CHEBI:3762) has part clorazepate monopotassium (CHEBI:59591)
dipotassium clorazepate (CHEBI:3762) has role anticonvulsant (CHEBI:35623)
dipotassium clorazepate (CHEBI:3762) has role anxiolytic drug (CHEBI:35474)
dipotassium clorazepate (CHEBI:3762) has role GABA modulator (CHEBI:50268)
dipotassium clorazepate (CHEBI:3762) has role prodrug (CHEBI:50266)
dipotassium clorazepate (CHEBI:3762) is a potassium salt (CHEBI:26218)
IUPAC Name
dipotassium 7-chloro-2-oxo-5-phenyl-2,3-dihydro-1H-1,4-benzodiazepine-3-carboxylate hydroxide
INNs Sources
clorazepate dipotassique ChemIDplus
clorazepato dipotasico ChemIDplus
dikalii clorazepas ChemIDplus
dipotassium clorazepate ChEBI
Synonyms Sources
bipotassium chlorazepate ChemIDplus
Clorazepate dipotassium KEGG DRUG
Manual Xrefs Databases
D00694 KEGG DRUG
DB00628 DrugBank
View more database links
Registry Numbers Types Sources
57109-90-7 CAS Registry Number KEGG DRUG
57109-90-7 CAS Registry Number ChemIDplus
9747917 Beilstein Registry Number Beilstein
Last Modified
08 June 2010