CHEBI:31317 - bufexamac

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ChEBI Name bufexamac
Definition A hydroxamic acid derived from phenylacetamide in which the benzene moiety is substituted at C-4 by a butoxy group. It has anti-inflammatory, analgesic, and antipyretic properties.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C12H17NO3
Net Charge 0
Average Mass 223.26830
Monoisotopic Mass 223.121
InChI InChI=1S/C12H17NO3/c1-2-3-8-16-11-6-4-10(5-7-11)9-12(14)13-15/h4-7,15H,2-3,8-9H2,1H3,(H,13,14)
Roles Classification
Biological Role(s): non-narcotic analgesic
A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.
Application(s): non-narcotic analgesic
A drug that has principally analgesic, antipyretic and anti-inflammatory actions. Non-narcotic analgesics do not bind to opioid receptors.
non-steroidal anti-inflammatory drug
An anti-inflammatory drug that is not a steroid. In addition to anti-inflammatory actions, non-steroidal anti-inflammatory drugs have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins.
A drug that prevents or reduces fever by lowering the body temperature from a raised state. An antipyretic will not affect the normal body temperature if one does not have fever. Antipyretics cause the hypothalamus to override an interleukin-induced increase in temperature. The body will then work to lower the temperature and the result is a reduction in fever.
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ChEBI Ontology
Outgoing bufexamac (CHEBI:31317) has role antipyretic (CHEBI:35493)
bufexamac (CHEBI:31317) has role non-narcotic analgesic (CHEBI:35481)
bufexamac (CHEBI:31317) has role non-steroidal anti-inflammatory drug (CHEBI:35475)
bufexamac (CHEBI:31317) is a aromatic ether (CHEBI:35618)
bufexamac (CHEBI:31317) is a hydroxamic acid (CHEBI:24650)
INNs Sources
bufexamac KEGG DRUG
bufexamaco ChemIDplus
bufexamacum ChemIDplus
Synonyms Sources
2-(p-Butoxyphenyl)-acetohydroxamic acid ChemIDplus
4-Butoxy-N-hydroxybenzeneacetamide ChemIDplus
4-Butoxyphenylacetohydroxamic acid ChemIDplus
Acide p-butoxyphenylacethydroxamique ChemIDplus
Bufexamic acid ChemIDplus
p-Butoxyphenylacetohydroxamic acid ChemIDplus
Manual Xrefs Databases
3047 DrugCentral
BE661226 Patent
Bufexamac Wikipedia
US3479396 Patent
View more database links
Registry Numbers Types Sources
2438-72-4 CAS Registry Number ChemIDplus
2646848 Reaxys Registry Number Reaxys
Citations Waiting for Citations Types Sources
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Last Modified
22 February 2017