CHEBI:145371 - binimetinib

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ChEBI Name binimetinib
Definition A member of the class of benzimidazoles that is 1-methyl-1H-benzimidazole which is substituted at positions 4, 5, and 6 by fluorine, (4-bromo-2-fluorophenyl)nitrilo, and N-(2-hydroxyethoxy)aminocarbonyl groups, respectively. It is a MEK1 and MEK2 inhibitor (IC50= 12 nM). Approved by the FDA for the treatment of patients with unresectable or metastatic melanoma with a BRAF V600E or V600K mutation in combination with encorafenib.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C17H15BrF2N4O3
Net Charge 0
Average Mass 441.233
Monoisotopic Mass 440.02956
InChI InChI=1S/C17H15BrF2N4O3/c1-24-8-21-16-13(24)7-10(17(26)23-27-5-4-25)15(14(16)20)22-12-3-2-9(18)6-11(12)19/h2-3,6-8,22,25H,4-5H2,1H3,(H,23,26)
Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): EC (mitogen-activated protein kinase) inhibitor
An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of mitogen-activated protein kinase (EC
apoptosis inducer
Any substance that induces the process of apoptosis (programmed cell death) in multi-celled organisms.
Application(s): antineoplastic agent
A substance that inhibits or prevents the proliferation of neoplasms.
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ChEBI Ontology
Outgoing binimetinib (CHEBI:145371) has role antineoplastic agent (CHEBI:35610)
binimetinib (CHEBI:145371) has role apoptosis inducer (CHEBI:68495)
binimetinib (CHEBI:145371) has role EC (mitogen-activated protein kinase) inhibitor (CHEBI:79091)
binimetinib (CHEBI:145371) is a benzimidazoles (CHEBI:22715)
binimetinib (CHEBI:145371) is a bromobenzenes (CHEBI:37149)
binimetinib (CHEBI:145371) is a hydroxamic acid ester (CHEBI:75606)
binimetinib (CHEBI:145371) is a monofluorobenzenes (CHEBI:83575)
binimetinib (CHEBI:145371) is a secondary amino compound (CHEBI:50995)
INNs Sources
binimetinib WHO MedNet
binimetinib WHO MedNet
binimétinib WHO MedNet
binimetinibum WHO MedNet
Synonyms Sources
5-[(4-bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-1,3-benzodiazole-6-carboxamide DrugBank
5-[(4-bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide ChEBI
ARRY 162 ChemIDplus
ARRY 438162 ChemIDplus
ARRY-162 DrugBank
ARRY-438162 DrugBank
MEK-162 DrugBank
MEK162 DrugBank
N-(2-hydroxyethoxy)-4-fluoro-5-(2-fluoro-4-bromophenylamino)-1-methyl-1H-benzoimidazole-6-carboxamide ChEBI
NVP-MEK162 DrugBank
Brand Name Source
Manual Xrefs Databases
Binimetinib Wikipedia
DB11967 DrugBank
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Registry Number Type Source
606143-89-9 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
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Last Modified
14 November 2019