CHEBI:143116 - BI00036838

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ChEBI Name BI00036838
ChEBI ID CHEBI:143116
Definition A member of the class of oxindoles that is 5-acetyl-3-methylidene-1,3-dihydro-2H-indol-2-one in which one of the hydrogens of the methylidene group is substituted by a 2,2-dimethylhydrazinyl group and the other hydrogen is substituted by an ethyl group. It is a DYRK1B kinase inhibitor.
Stars This entity has been manually annotated by the ChEBI Team.
Submitter Tim Willson
Supplier Information
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Formula C15H19N3O2
Net Charge 0
Average Mass 273.336
Monoisotopic Mass 273.14773
InChI InChI=1S/C15H19N3O2/c1-5-12(17-18(3)4)14-11-8-10(9(2)19)6-7-13(11)16-15(14)20/h6-8,17H,5H2,1-4H3,(H,16,20)/b14-12+
InChIKey DVQQRISDKCELNQ-WYMLVPIESA-N
SMILES O=C(C)C=1C=CC2=C(C1)/C(=C(/CC)\NN(C)C)/C(N2)=O
Roles Classification
Biological Role(s): EC 2.7.12.* [dual-specificity kinases (those acting on Ser/Thr and Tyr residues)] inhibitor
An EC 2.7.* (P-containing group transferase) inhibitor that interferes with the action of duals specificity kinases acting on Ser/Thr and Tyr residues.
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ChEBI Ontology
Outgoing BI00036838 (CHEBI:143116) has role EC 2.7.12.* [dual-specificity kinases (those acting on Ser/Thr and Tyr residues)] inhibitor (CHEBI:88285)
BI00036838 (CHEBI:143116) is a aromatic ketone (CHEBI:76224)
BI00036838 (CHEBI:143116) is a hydrazines (CHEBI:24631)
BI00036838 (CHEBI:143116) is a methyl ketone (CHEBI:51867)
BI00036838 (CHEBI:143116) is a oxindoles (CHEBI:38459)
IUPAC Name
(3E)-5-acetyl-3-[1-(2,2-dimethylhydrazinyl)propylidene]-1,3-dihydro-2H-indol-2-one
Synonym Source
(E)-5-acetyl-3-(1-(2,2-dimethylhydrazineyl)propylidene)indolin-2-one ChEBI
Manual Xref Database
WO2005087727 Patent
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Last Modified
21 May 2019
Submitter Remark
2019-02-19 19:43:20.0 Tim Willson DYRK1B kinase inhibitor