CHEBI:142489 - CHIC-35

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ChEBI Name CHIC-35
Definition An organic heterotricyclic compound resulting from the formal fusion of the 2-3 bond of 5-chloroindole with the 2-3 bond of cycloheptanecarboxamide (the S enantiomer). It is a potent, cell-permeable, metabolically stable and selective inhibitor of the deacetylase SIRT1.
Stars This entity has been manually annotated by the ChEBI Team.
Submitter Ceri
Supplier Information
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Formula C14H15ClN2O
Net Charge 0
Average Mass 262.735
Monoisotopic Mass 262.08729
InChI InChI=1S/C14H15ClN2O/c15-8-5-6-12-11(7-8)9-3-1-2-4-10(14(16)18)13(9)17-12/h5-7,10,17H,1-4H2,(H2,16,18)/t10-/m0/s1
SMILES C1C2=C(NC=3C2=CC(=CC3)Cl)[C@@H](C(=O)N)CCC1
Roles Classification
Biological Role(s): EC (histone deacetylase) inhibitor
An EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the function of histone deacetylase (EC
View more via ChEBI Ontology
ChEBI Ontology
Outgoing CHIC-35 (CHEBI:142489) has role EC (histone deacetylase) inhibitor (CHEBI:61115)
CHIC-35 (CHEBI:142489) is a aromatic compound (CHEBI:33655)
CHIC-35 (CHEBI:142489) is a organic heterotricyclic compound (CHEBI:26979)
CHIC-35 (CHEBI:142489) is a organochlorine compound (CHEBI:36683)
CHIC-35 (CHEBI:142489) is a primary carboxamide (CHEBI:140324)
Synonyms Sources
Compound (S)-35 SUBMITTER
SIRT1 Inhibitor IV, (S)-35 SUBMITTER
Registry Numbers Types Sources
10274604 Reaxys Registry Number Reaxys
848193-72-6 CAS Registry Number SUBMITTER
Citations Waiting for Citations Types Sources
16335928 PubMed citation Europe PMC
21699209 PubMed citation Europe PMC
23499872 PubMed citation Europe PMC
26792944 PubMed citation Europe PMC
Last Modified
02 November 2018