CHEBI:9754 - tris

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ChEBI Name tris
ChEBI ID CHEBI:9754
Definition A primary amino compound that is tert-butylamine in which one hydrogen attached to each methyl group is replaced by a hydroxy group. A compound widely used as a biological buffer substance in the pH range 7—9; pKa = 8.3 at 20 °C; pKa = 7.82 at 37 °C.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C4H11NO3
Net Charge 0
Average Mass 121.13500
Monoisotopic Mass 121.074
InChI InChI=1S/C4H11NO3/c5-4(1-6,2-7)3-8/h6-8H,1-3,5H2
InChIKey LENZDBCJOHFCAS-UHFFFAOYSA-N
SMILES NC(CO)(CO)CO
Roles Classification
Chemical Role(s): buffer
Any substance or mixture of substances that, in solution (typically aqueous), resists change in pH upon addition of small amounts of acid or base.
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ChEBI Ontology
Outgoing tris (CHEBI:9754) has role buffer (CHEBI:35225)
tris (CHEBI:9754) is a primary amino compound (CHEBI:50994)
tris (CHEBI:9754) is a triol (CHEBI:27136)
tris (CHEBI:9754) is conjugate base of Htris (CHEBI:46097)
Incoming N-tris(hydroxymethyl)methylglycine (CHEBI:39063) has functional parent tris (CHEBI:9754)
bis-tris (CHEBI:41250) has functional parent tris (CHEBI:9754)
bis-tris propane (CHEBI:40947) has functional parent tris (CHEBI:9754)
TES (CHEBI:39035) has functional parent tris (CHEBI:9754)
Htris (CHEBI:46097) is conjugate acid of tris (CHEBI:9754)
IUPAC Name
2-amino-2-(hydroxymethyl)propane-1,3-diol
Synonyms Sources
1,1,1-tris(hydroxymethyl)methanamine NIST Chemistry WebBook
2-Amino-2-(hydroxymethyl)-1,3-propanediol KEGG COMPOUND
aminotris(hydroxymethyl)methane ChemIDplus
THAM
Note: (2006-11-28) Acronym for Tris(Hydroxymethyl)AminoMethane.
ChemIDplus
Tris ChemIDplus
Tris amino NIST Chemistry WebBook
Tris base NIST Chemistry WebBook
Tris buffer ChemIDplus
tris(hydroxymethyl)aminomethane ChemIDplus
Tris-base ChemIDplus
Trometamol KEGG COMPOUND
Tromethamine KEGG COMPOUND
Brand Name Source
Trizma
Note: (2012-08-01) Trizma is a registered trademark of Sigma-Aldrich Co.
ChEBI
Database Links Databases
2771 DrugCentral
C07182 KEGG COMPOUND
D00396 KEGG DRUG
DB03754 DrugBank
Tris Wikipedia
TRS PDBeChem
View more database links
Registry Numbers Types Sources
217857 Gmelin Registry Number Gmelin
741883 Reaxys Registry Number Reaxys
741883 Beilstein Registry Number Beilstein
77-86-1 CAS Registry Number NIST Chemistry WebBook
77-86-1 CAS Registry Number ChemIDplus
Citation Waiting for Citations Type Source
22553829 PubMed citation Europe PMC
Last Modified
22 February 2017