trichlormethiazide (CHEBI:9683)

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ChEBI Name	trichlormethiazide

ChEBI ID	CHEBI:9683

Definition	A benzothiadiazine, hydrogenated at positions 2, 3 and 4 and substituted with an aminosulfonyl group at C-7, a chloro substituent at C-6 and a dichloromethyl group at C-3 and with S-1 as an S,S-dioxide. A sulfonamide antibiotic, it is used as a diuretic to treat oedema (including that associated with heart failure) and hypertension.

Stars	This entity has been manually annotated by the ChEBI Team.

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Formula

C8H8Cl3N3O4S2

Net Charge

Average Mass

380.658

Monoisotopic Mass

378.90218

InChI

InChI=1S/C8H8Cl3N3O4S2/c9-3-1-4-6(2-5(3)19(12,15)16)20(17,18)14-8(13-4)7(10)11/h1-2,7-8,13-14H,(H2,12,15,16)

InChIKey

LMJSLTNSBFUCMU-UHFFFAOYSA-N

SMILES

C12=C(NC(C(Cl)Cl)NS1(=O)=O)C=C(Cl)C(=C2)S(N)(=O)=O

Roles Classification
Biological Role(s):	antimicrobial agent A substance that kills or slows the growth of microorganisms, including bacteria, viruses, fungi and protozoans. (via sulfonamide antibiotic )

Application(s):	diuretic An agent that promotes the excretion of urine through its effects on kidney function. antihypertensive agent Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism.

ChEBI Ontology
Outgoing	trichlormethiazide (CHEBI:9683) has role antihypertensive agent (CHEBI:35674) trichlormethiazide (CHEBI:9683) has role diuretic (CHEBI:35498) trichlormethiazide (CHEBI:9683) is a benzothiadiazine (CHEBI:50265) trichlormethiazide (CHEBI:9683) is a sulfonamide antibiotic (CHEBI:87228)

IUPAC Name

6-chloro-3-(dichloromethyl)-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide

Synonym	Source
hydrotrichlorothiazide	ChemIDplus

Registry Number	Type	Source
133-67-5	CAS Registry Number	ChemIDplus

Last Modified

25 May 2018