CHEBI:87237 - PF-4800567

Main ChEBI Ontology Automatic Xrefs Reactions Pathways Models
ChEBI Name PF-4800567
Definition A pyrazolopyrimidine that is 1H-pyrazolo[3,4-d]pyrimidin-4-amine which is substituted at positions 1 and 3 by tetrahydro-2H-pyran-4-yl and (m-chlorophenoxy)methyl groups, respectively. It is a selective inhibitor of the ε isoform of casein kinase 1 (CK1ε).
Stars This entity has been manually annotated by the ChEBI Team.
Submitter TheOtherDave
Supplier Information
Download Molfile XML SDF
more structures >>
Wikipedia License
Waiting for wikipedia content
Read full article at Wikipedia
Formula C17H18ClN5O2
Net Charge 0
Average Mass 359.81000
Monoisotopic Mass 359.11490
InChI InChI=1S/C17H18ClN5O2/c18-11-2-1-3-13(8-11)25-9-14-15-16(19)20-10-21-17(15)23(22-14)12-4-6-24-7-5-12/h1-3,8,10,12H,4-7,9H2,(H2,19,20,21)
SMILES Nc1ncnc2n(nc(COc3cccc(Cl)c3)c12)C1CCOCC1
Roles Classification
Biological Role(s): EC (non-specific serine/threonine protein kinase) inhibitor
An EC 2.7.11.* (protein-serine/threonine kinase) inhibitor that interferes with the action of non-specific serine/threonine protein kinase (EC, a kinase enzyme involved in phosphorylation of hydroxy group of serine or threonine.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing PF-4800567 (CHEBI:87237) has role EC (non-specific serine/threonine protein kinase) inhibitor (CHEBI:50925)
PF-4800567 (CHEBI:87237) is a aromatic ether (CHEBI:35618)
PF-4800567 (CHEBI:87237) is a monochlorobenzenes (CHEBI:83403)
PF-4800567 (CHEBI:87237) is a oxanes (CHEBI:46942)
PF-4800567 (CHEBI:87237) is a pyrazolopyrimidine (CHEBI:38669)
Synonym Source
PF-480 ChEBI
Manual Xref Database
PF-4800567 Wikipedia
View more database links
Registry Number Type Source
24283230 Reaxys Registry Number Reaxys
Citations Waiting for Citations Types Sources
19458106 PubMed citation Europe PMC
20577972 PubMed citation Europe PMC
20696890 PubMed citation Europe PMC
21258417 PubMed citation Europe PMC
22089318 PubMed citation Europe PMC
22944772 PubMed citation Europe PMC
23106386 PubMed citation Europe PMC
23349822 PubMed citation Europe PMC
24076244 PubMed citation Europe PMC
Last Modified
03 August 2015