CHEBI:8459 - promazine

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ChEBI Name promazine
ChEBI ID CHEBI:8459
Definition A phenothiazine deriative in which the phenothiazine tricycle has a 3-(dimethylaminopropyl) group at the N-10 position.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C17H20N2S
Net Charge 0
Average Mass 284.42018
Monoisotopic Mass 284.135
InChI InChI=1S/C17H20N2S/c1-18(2)12-7-13-19-14-8-3-5-10-16(14)20-17-11-6-4-9-15(17)19/h3-6,8-11H,7,12-13H2,1-2H3
InChIKey ZGUGWUXLJSTTMA-UHFFFAOYSA-N
SMILES CN(C)CCCN1c2ccccc2Sc2ccccc12
Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): dopaminergic antagonist
A drug that binds to but does not activate dopamine receptors, thereby blocking the actions of dopamine or exogenous agonists.
H1-receptor antagonist
H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine.
muscarinic antagonist
A drug that binds to but does not activate muscarinic cholinergic receptors, thereby blocking the actions of endogenous acetylcholine or exogenous agonists.
serotonergic antagonist
Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists.
EC 3.4.21.26 (prolyl oligopeptidase) inhibitor
Any EC 3.4.21.* (serine endopeptidase) inhibitor that interferes with the action of prolyl oligopeptidase (EC 3.4.21.26).
Application(s): dopaminergic antagonist
A drug that binds to but does not activate dopamine receptors, thereby blocking the actions of dopamine or exogenous agonists.
H1-receptor antagonist
H1-receptor antagonists are the drugs that selectively bind to but do not activate histamine H1 receptors, thereby blocking the actions of endogenous histamine.
muscarinic antagonist
A drug that binds to but does not activate muscarinic cholinergic receptors, thereby blocking the actions of endogenous acetylcholine or exogenous agonists.
serotonergic antagonist
Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists.
phenothiazine antipsychotic drug

antiemetic
A drug used to prevent nausea or vomiting. An antiemetic may act by a wide range of mechanisms: it might affect the medullary control centres (the vomiting centre and the chemoreceptive trigger zone) or affect the peripheral receptors.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing promazine (CHEBI:8459) has role antiemetic (CHEBI:50919)
promazine (CHEBI:8459) has role dopaminergic antagonist (CHEBI:48561)
promazine (CHEBI:8459) has role EC 3.4.21.26 (prolyl oligopeptidase) inhibitor (CHEBI:76779)
promazine (CHEBI:8459) has role H1-receptor antagonist (CHEBI:37955)
promazine (CHEBI:8459) has role muscarinic antagonist (CHEBI:48876)
promazine (CHEBI:8459) has role phenothiazine antipsychotic drug (CHEBI:37930)
promazine (CHEBI:8459) has role serotonergic antagonist (CHEBI:48279)
promazine (CHEBI:8459) is a phenothiazines (CHEBI:38093)
promazine (CHEBI:8459) is a tertiary amine (CHEBI:32876)
Incoming promazine hydrochloride (CHEBI:8460) has part promazine (CHEBI:8459)
IUPAC Name
N,N-dimethyl-3-(10H-phenothiazin-10-yl)propan-1-amine
INNs Sources
promazina ChemIDplus
promazine ChEBI
promazinum ChemIDplus
Synonyms Sources
10-(3-(Dimethylamino)propyl)phenothiazine ChemIDplus
N-(3-Dimethylaminopropyl)phenothiazine ChemIDplus
N-Dimethylamino-1-methylethyl thiodiphenylamine ChemIDplus
Promazine KEGG COMPOUND
Manual Xrefs Databases
2284 DrugCentral
C07379 KEGG COMPOUND
D08430 KEGG DRUG
DB00420 DrugBank
HMDB0014564 HMDB
LSM-2137 LINCS
Promazine Wikipedia
US2519886 Patent
View more database links
Registry Numbers Types Sources
244925 Reaxys Registry Number Reaxys
244925 Beilstein Registry Number Beilstein
58-40-2 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
1650428 PubMed citation Europe PMC
18423639 PubMed citation Europe PMC
19306624 PubMed citation Europe PMC
20825390 PubMed citation Europe PMC
Last Modified
22 February 2017