CHEBI:76290 - PhIP

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ChEBI Name PhIP
ChEBI ID CHEBI:76290
Definition An imidazopyridine that is 1H--imidazo[4,5-b]pyridine which is substituted at positions 1, 2, and 6 by methyl, amino, and phenyl groups, respectively. It is the most abundant of the mutagenic heterocyclic amines found in cooked meat and fish.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C13H12N4
Net Charge 0
Average Mass 224.26120
Monoisotopic Mass 224.106
InChI InChI=1S/C13H12N4/c1-17-11-7-10(9-5-3-2-4-6-9)8-15-12(11)16-13(17)14/h2-8H,1H3,(H2,14,15,16)
InChIKey UQVKZNNCIHJZLS-UHFFFAOYSA-N
SMILES Cn1c(N)nc2ncc(cc12)-c1ccccc1
Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): carcinogenic agent
A role played by a chemical compound which is known to induce a process of carcinogenesis by corrupting normal cellular pathways, leading to the acquistion of tumoral capabilities.
mutagen
An agent that increases the frequency of mutations above the normal background level, usually by interacting directly with DNA and causing it damage, including base substitution.
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ChEBI Ontology
Outgoing PhIP (CHEBI:76290) has role carcinogenic agent (CHEBI:50903)
PhIP (CHEBI:76290) has role mutagen (CHEBI:25435)
PhIP (CHEBI:76290) is a imidazopyridine (CHEBI:46908)
PhIP (CHEBI:76290) is a primary amino compound (CHEBI:50994)
Incoming N-hydroxy-PhIP (CHEBI:133920) has functional parent PhIP (CHEBI:76290)
IUPAC Name
1-methyl-6-phenyl-1H-imidazo[4,5-b]pyridin-2-amine
Synonyms Sources
2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine ChemIDplus
PhIP KEGG COMPOUND
Database Links Databases
2-Amino-1-methyl-6-phenylimidazo(4,5-b)pyridine Wikipedia
C16038 KEGG COMPOUND
HMDB0041008 HMDB
PIQ PDBeChem
View more database links
Registry Numbers Types Sources
105650-23-5 CAS Registry Number ChemIDplus
5951264 Reaxys Registry Number Reaxys
Citations Waiting for Citations Types Sources
10944558 PubMed citation Europe PMC
11921178 PubMed citation Europe PMC
20036730 PubMed citation Europe PMC
23265474 PubMed citation Europe PMC
23306951 PubMed citation Europe PMC
23313794 PubMed citation Europe PMC
23466459 PubMed citation Europe PMC
24128508 PubMed citation Europe PMC
Last Modified
20 April 2017