CHEBI:76016 - vortioxetine

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ChEBI Name vortioxetine
ChEBI ID CHEBI:76016
Definition An N-arylpiperazine in which the aryl group is specified as 2-[(2,4-dimethylphenyl)sulfanyl]phenyl. Used (as its hydrobromide salt) for treatment of major depressive disorder.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C18H22N2S
Net Charge 0
Average Mass 298.44600
Monoisotopic Mass 298.150
Roles Classification
Chemical Role(s): Bronsted base
A molecular entity capable of accepting a hydron from a donor (Bronsted acid).
(via organic amino compound )
Biological Role(s): serotonergic agonist
An agent that has an affinity for serotonin receptors and is able to mimic the effects of serotonin by stimulating the physiologic activity at the cell receptors. Serotonin agonists are used as antidepressants, anxiolytics, and in the treatment of migraine disorders.
serotonergic antagonist
Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists.
Application(s): antidepressant
Antidepressants are mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions.
anxiolytic drug
Anxiolytic drugs are agents that alleviate anxiety, tension, and anxiety disorders, promote sedation, and have a calming effect without affecting clarity of consciousness or neurologic conditions.
serotonergic agonist
An agent that has an affinity for serotonin receptors and is able to mimic the effects of serotonin by stimulating the physiologic activity at the cell receptors. Serotonin agonists are used as antidepressants, anxiolytics, and in the treatment of migraine disorders.
serotonergic antagonist
Drugs that bind to but do not activate serotonin receptors, thereby blocking the actions of serotonin or serotonergic agonists.
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ChEBI Ontology
Outgoing vortioxetine (CHEBI:76016) has role antidepressant (CHEBI:35469)
vortioxetine (CHEBI:76016) has role anxiolytic drug (CHEBI:35474)
vortioxetine (CHEBI:76016) has role serotonergic agonist (CHEBI:35941)
vortioxetine (CHEBI:76016) has role serotonergic antagonist (CHEBI:48279)
vortioxetine (CHEBI:76016) is a N-arylpiperazine (CHEBI:46848)
vortioxetine (CHEBI:76016) is a aryl sulfide (CHEBI:35683)
vortioxetine (CHEBI:76016) is conjugate base of vortioxetine(1+) (CHEBI:76017)
Incoming vortioxetine(1+) (CHEBI:76017) is conjugate acid of vortioxetine (CHEBI:76016)
IUPAC Name
1-{2-[(2,4-dimethylphenyl)sulfanyl]phenyl}piperazine
INNs Sources
vortioxetina WHO MedNet
vortioxetine WHO MedNet
vortioxétine WHO MedNet
vortioxetinum WHO MedNet
Synonym Source
Lu AA21004 ChemIDplus
Manual Xrefs Databases
4806 DrugCentral
D10184 KEGG DRUG
Vortioxetine Wikipedia
WO2008113359 Patent
View more database links
Registry Numbers Types Sources
11341374 Reaxys Registry Number Reaxys
508233-74-7 CAS Registry Number KEGG DRUG
508233-74-7 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
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Last Modified
22 February 2017