CHEBI:7582 - nitrendipine

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ChEBI Name nitrendipine
ChEBI ID CHEBI:7582
Definition A dihydropyridine that is 1,4-dihydropyridine substituted by methyl groups at positions 2 and 6, a 3-nitrophenyl group at position 4, a ethoxycarbonyl group at position 3 and a methoxycarbonyl group at position 5. It is a calcium-channel blocker used in the treatment of hypertension.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C18H20N2O6
Net Charge 0
Average Mass 360.36120
Monoisotopic Mass 360.132
InChI InChI=1S/C18H20N2O6/c1-5-26-18(22)15-11(3)19-10(2)14(17(21)25-4)16(15)12-7-6-8-13(9-12)20(23)24/h6-9,16,19H,5H2,1-4H3
InChIKey PVHUJELLJLJGLN-UHFFFAOYSA-N
SMILES CCOC(=O)C1=C(C)NC(C)=C(C1c1cccc(c1)[N+]([O-])=O)C(=O)OC
Roles Classification
Biological Role(s): calcium channel blocker
One of a class of drugs that acts by selective inhibition of calcium influx through cell membranes or on the release and binding of calcium in intracellular pools.
Application(s): antihypertensive agent
Any drug used in the treatment of acute or chronic vascular hypertension regardless of pharmacological mechanism.
vasodilator agent
A drug used to cause dilation of the blood vessels.
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ChEBI Ontology
Outgoing nitrendipine (CHEBI:7582) has role antihypertensive agent (CHEBI:35674)
nitrendipine (CHEBI:7582) has role calcium channel blocker (CHEBI:38215)
nitrendipine (CHEBI:7582) has role vasodilator agent (CHEBI:35620)
nitrendipine (CHEBI:7582) is a C-nitro compound (CHEBI:35716)
nitrendipine (CHEBI:7582) is a dicarboxylic acids and O-substituted derivatives (CHEBI:131927)
nitrendipine (CHEBI:7582) is a diester (CHEBI:51307)
nitrendipine (CHEBI:7582) is a dihydropyridine (CHEBI:50075)
nitrendipine (CHEBI:7582) is a ethyl ester (CHEBI:23990)
nitrendipine (CHEBI:7582) is a methyl ester (CHEBI:25248)
IUPAC Name
ethyl methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
INNs Sources
nitrendipine ChemIDplus
nitrendipino ChemIDplus
nitrendipinum ChemIDplus
Synonyms Sources
1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid ethyl methyl ester ChemIDplus
BAY e 5009 ChemIDplus
Brand Names Sources
Bayotensin ChemIDplus
Baypress KEGG DRUG
Bylotensin ChEBI
Deiten ChEBI
Nidrel ChemIDplus
Manual Xrefs Databases
1947 DrugCentral
C07713 KEGG COMPOUND
CN101416954 Patent
D00629 KEGG DRUG
DB01054 DrugBank
DE2117571 Patent
HMDB0015187 HMDB
LSM-1246 LINCS
Nitrendipine Wikipedia
US3799934 Patent
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Registry Numbers Types Sources
39562-70-4 CAS Registry Number KEGG COMPOUND
39562-70-4 CAS Registry Number NIST Chemistry WebBook
498823 Reaxys Registry Number Reaxys
Citations Waiting for Citations Types Sources
1725797 PubMed citation Europe PMC
1790544 PubMed citation Europe PMC
20398559 PubMed citation Europe PMC
21811924 PubMed citation Europe PMC
23648675 PubMed citation Europe PMC
6085389 PubMed citation Europe PMC
Last Modified
09 March 2018