CHEBI:70705 - vilazodone hydrochloride

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ChEBI Name vilazodone hydrochloride
ChEBI ID CHEBI:70705
Definition A hydrochloride obtained by reaction of vilazodone with one equivalent of hydrochloric acid. Used for the treatment of major depressive disorder.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
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Formula C26H28ClN5O2
Net Charge 0
Average Mass 477.98600
Monoisotopic Mass 477.19315
InChI InChI=1S/C26H27N5O2.ClH/c27-16-18-4-6-23-22(13-18)19(17-29-23)3-1-2-8-30-9-11-31(12-10-30)21-5-7-24-20(14-21)15-25(33-24)26(28)32;/h4-7,13-15,17,29H,1-3,8-12H2,(H2,28,32);1H
InChIKey RPZBRGFNBNQSOP-UHFFFAOYSA-N
SMILES Cl.NC(=O)c1cc2cc(ccc2o1)N1CCN(CCCCc2c[nH]c3ccc(cc23)C#N)CC1
Roles Classification
Biological Role(s): serotonin uptake inhibitor
A compound that specifically inhibits the reuptake of serotonin in the brain. This increases the serotonin concentration in the synaptic cleft which then activates serotonin receptors to a greater extent.
serotonergic agonist
An agent that has an affinity for serotonin receptors and is able to mimic the effects of serotonin by stimulating the physiologic activity at the cell receptors. Serotonin agonists are used as antidepressants, anxiolytics, and in the treatment of migraine disorders.
Application(s): antidepressant
Antidepressants are mood-stimulating drugs used primarily in the treatment of affective disorders and related conditions.
serotonin uptake inhibitor
A compound that specifically inhibits the reuptake of serotonin in the brain. This increases the serotonin concentration in the synaptic cleft which then activates serotonin receptors to a greater extent.
serotonergic agonist
An agent that has an affinity for serotonin receptors and is able to mimic the effects of serotonin by stimulating the physiologic activity at the cell receptors. Serotonin agonists are used as antidepressants, anxiolytics, and in the treatment of migraine disorders.
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ChEBI Ontology
Outgoing vilazodone hydrochloride (CHEBI:70705) has part vilazodone(1+) (CHEBI:70706)
vilazodone hydrochloride (CHEBI:70705) has role antidepressant (CHEBI:35469)
vilazodone hydrochloride (CHEBI:70705) has role serotonergic agonist (CHEBI:35941)
vilazodone hydrochloride (CHEBI:70705) has role serotonin uptake inhibitor (CHEBI:50949)
vilazodone hydrochloride (CHEBI:70705) is a hydrochloride (CHEBI:36807)
IUPAC Name
5-{4-[4-(5-cyano-1H-indol-3-yl)butyl]piperazin-1-yl}-1-benzofuran-2-carboxamide hydrochloride
Synonyms Sources
4-(2-carbamoyl-1-benzofuran-5-yl)-1-[4-(5-cyano-1H-indol-3-yl)butyl]piperazin-1-ium chloride IUPAC
EMD 68 843 ChemIDplus
Vilazodone HCl ChemIDplus
vilazodone monohydrochloride ChEBI
Brand Name Source
Viibryd KEGG DRUG
Manual Xrefs Databases
D09699 KEGG DRUG
DB06684 DrugBank
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Registry Numbers Types Sources
163521-08-2 CAS Registry Number KEGG DRUG
163521-08-2 CAS Registry Number ChemIDplus
9830698 Reaxys Registry Number Reaxys
Citations Waiting for Citations Types Sources
21752782 PubMed citation Europe PMC
22013560 PubMed citation Europe PMC
22346333 PubMed citation Europe PMC
22935937 PubMed citation Europe PMC
Last Modified
15 November 2012