CHEBI:6801 - metformin

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ChEBI Name metformin
ChEBI ID CHEBI:6801
Definition A member of the class of guanidines that is biguanide the carrying two methyl substituents at position 1.
Stars This entity has been manually annotated by the ChEBI Team.
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Formula C4H11N5
Net Charge 0
Average Mass 129.16384
Monoisotopic Mass 129.101
InChI InChI=1S/C4H11N5/c1-9(2)4(7)8-3(5)6/h1-2H3,(H5,5,6,7,8)
InChIKey XZWYZXLIPXDOLR-UHFFFAOYSA-N
SMILES CN(C)C(=N)NC(N)=N
Roles Classification
Chemical Role(s): environmental contaminant
Any minor or unwanted substance introduced into the environment that can have undesired effects.
Biological Role(s): xenobiotic
A xenobiotic (Greek, xenos "foreign"; bios "life") is a compound that is foreign to a living organism. Principal xenobiotics include: drugs, carcinogens and various compounds that have been introduced into the environment by artificial means.
Application(s): hypoglycemic agent
A drug which lowers the blood glucose level.
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ChEBI Ontology
Outgoing metformin (CHEBI:6801) has functional parent biguanide (CHEBI:3095)
metformin (CHEBI:6801) has role environmental contaminant (CHEBI:78298)
metformin (CHEBI:6801) has role hypoglycemic agent (CHEBI:35526)
metformin (CHEBI:6801) has role xenobiotic (CHEBI:35703)
metformin (CHEBI:6801) is a guanidines (CHEBI:24436)
metformin (CHEBI:6801) is conjugate base of metformin(1+) (CHEBI:90688)
Incoming metformin(1+) (CHEBI:90688) is conjugate acid of metformin (CHEBI:6801)
IUPAC Name
N,N-dimethylimidodicarbonimidic diamide
Synonyms Sources
1,1-Dimethylbiguanide ChemIDplus
Metformin KEGG COMPOUND
Database Links Databases
1725 DrugCentral
C07151 KEGG COMPOUND
D04966 KEGG DRUG
DB00331 DrugBank
HMDB0001921 HMDB
LSM-4730 LINCS
Metformin Wikipedia
View more database links
Registry Numbers Types Sources
606492 Reaxys Registry Number Reaxys
657-24-9 CAS Registry Number ChemIDplus
Citations Waiting for Citations Types Sources
11772907 PubMed citation Europe PMC
17062558 PubMed citation Europe PMC
18212742 PubMed citation Europe PMC
18608522 PubMed citation Europe PMC
24428821 PubMed citation Europe PMC
Last Modified
22 February 2017
General Comment
2014-10-29 Stravs M, Schymanski E, Singer H, Department of Environmental Chemistry, Eawag