CHEBI:66899 - tafluprost

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ChEBI Name tafluprost ChEBI ID CHEBI:66899 Definition A prostaglandin Fα that is prostaglandin F2α in which the carboxylic acid function has been converted to the corresponding isopropyl ester and the 3-hydroxy-1-octenyl side-chain is substituted by 3,3-difluoro-4-phenoxybut-1-enyl. Used for treatment of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension. Stars This entity has been manually annotated by the ChEBI Team. Supplier Information Download Molfile XML SDF Find compounds which contain this structure Find compounds which resemble this structure Take structure to the Advanced Search Wikipedia License Read full article at Wikipedia Formula C25H34F2O5 Net Charge 0 Average Mass 452.53130 Monoisotopic Mass 452.23743 InChI InChI=1S/C25H34F2O5/c1-18(2)32-24(30)13-9-4-3-8-12-20-21(23(29)16-22(20)28)14-15-25(26,27)17-31-19-10-6-5-7-11-19/h3,5-8,10-11,14-15,18,20-23,28-29H,4,9,12-13,16-17H2,1-2H3/b8-3-,15-14+/t20-,21-,22+,23-/m1/s1 InChIKey WSNODXPBBALQOF-VEJSHDCNSA-N SMILES CC(C)OC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1\C=C\C(F)(F)COc1ccccc1 Roles Classification Biological Role(s): prostaglandin receptor agonist An agonist that binds to and activates prostaglandin receptors. View more via ChEBI Ontology ChEBI Ontology Outgoing tafluprost (CHEBI:66899) has functional parent prostaglandin F2α (CHEBI:15553) tafluprost (CHEBI:66899) has role prostaglandin receptor agonist (CHEBI:66900) tafluprost (CHEBI:66899) is a isopropyl ester (CHEBI:35725) tafluprost (CHEBI:66899) is a organofluorine compound (CHEBI:37143) tafluprost (CHEBI:66899) is a prostaglandins Fα (CHEBI:36066) IUPAC Name isopropyl (5Z)-7-{(1R,2R,3R,5S)-2-[(1E)-3,3-difluoro-4-phenoxybut-1-en-1-yl]-3,5-dihydroxycyclopentyl}hept-5-enoate INN Source tafluprost KEGG DRUG Brand Name Source Zioptan ChemIDplus Manual Xrefs Databases 4229 DrugCentral D06274 KEGG DRUG EP1825855 Patent Tafluprost Wikipedia View more database links Registry Numbers Types Sources 209860-87-7 CAS Registry Number ChemIDplus 209860-87-7 CAS Registry Number KEGG DRUG 9668502 Reaxys Registry Number Reaxys Citations Types Sources 21423041 PubMed citation Europe PMC 21491995 PubMed citation Europe PMC 22049909 PubMed citation Europe PMC 22107041 PubMed citation Europe PMC 22275814 PubMed citation Europe PMC 22310086 PubMed citation Europe PMC 22399693 PubMed citation Europe PMC 22499235 PubMed citation Europe PMC 22583577 PubMed citation Europe PMC 22606063 PubMed citation Europe PMC 22654492 PubMed citation Europe PMC 22669351 PubMed citation Europe PMC 22690824 PubMed citation Europe PMC 22695966 PubMed citation Europe PMC Last Modified 09 March 2018