CHEBI:65329 - LY294002

Main ChEBI Ontology Automatic Xrefs Reactions Pathways Models
ChEBI Name LY294002
ChEBI ID CHEBI:65329
Definition A chromone substituted with a phenyl group at position 8 and a morpholine group at position 2.
Stars This entity has been manually annotated by the ChEBI Team.
Supplier Information
Download Molfile XML SDF
Formula C19H17NO3
Net Charge 0
Average Mass 307.34320
Monoisotopic Mass 307.121
InChI InChI=1S/C19H17NO3/c21-17-13-18(20-9-11-22-12-10-20)23-19-15(7-4-8-16(17)19)14-5-2-1-3-6-14/h1-8,13H,9-12H2
InChIKey CZQHHVNHHHRRDU-UHFFFAOYSA-N
SMILES O=c1cc(oc2c(cccc12)-c1ccccc1)N1CCOCC1
Roles Classification
Biological Role(s): autophagy inhibitor
Any compound that inhibits the process of autophagy (the self-digestion of one or more components of a cell through the action of enzymes originating within the same cell).
EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor
An inhibitor of phosphatidylinositol 3-kinase, EC 2.7.1.137, a family of related enzymes capable of phosphorylating the 3 position hydroxy group of the inositol ring of a phosphatidylinositol.
View more via ChEBI Ontology
ChEBI Ontology
Outgoing LY294002 (CHEBI:65329) has role autophagy inhibitor (CHEBI:88230)
LY294002 (CHEBI:65329) has role EC 2.7.1.137 (phosphatidylinositol 3-kinase) inhibitor (CHEBI:50914)
LY294002 (CHEBI:65329) is a chromones (CHEBI:23238)
LY294002 (CHEBI:65329) is a morpholines (CHEBI:38785)
LY294002 (CHEBI:65329) is a organochlorine compound (CHEBI:36683)
IUPAC Name
2-(morpholin-4-yl)-8-phenyl-4H-chromen-4-one
Synonyms Sources
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one ChemIDplus
2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one KEGG COMPOUND
LY 294002 KEGG COMPOUND
Database Links Databases
C15195 KEGG COMPOUND
DB02656 DrugBank
LSM-2597 LINCS
LY2 PDBeChem
View more database links
Registry Numbers Types Sources
154447-36-6 CAS Registry Number ChemIDplus
8156139 Reaxys Registry Number Reaxys
Citations Waiting for Citations Types Sources
11517177 PubMed citation Europe PMC
18621031 PubMed citation Europe PMC
24666011 PubMed citation Europe PMC
24975165 PubMed citation Europe PMC
25351625 PubMed citation Europe PMC
25488290 PubMed citation Europe PMC
26424017 PubMed citation Europe PMC
Last Modified
25 February 2016